نتایج جستجو برای: colorectal tumors
تعداد نتایج: 252252 فیلتر نتایج به سال:
Although conventional colonoscopy is considered the gold standard for detecting colorectal tumors, accurate staging is often difficult because advanced histology may be present in small colorectal lesions. We collected DNA present in mucosal wash fluid from patients undergoing colonoscopy and then assessed the methylation levels of four genes frequently methylated in colorectal cancers to detec...
Backgrounds: SIRT1 plays an important role in many physiological processes, including metabolism, neuronal protection, senecence and inflammatory, by staging histones and multiple transcription factors. However, the complex mechanisms of SIRT1 signaling in tumors are not yet fully understood, as it acts as both an oncogen and a tumor suppressor. On the other hand, it has been shown that the Lnc...
Timely detection of colorectal cancer metastases may permit improvements in their clinical management. Here, we investigated a putative role for bone marrow-derived cells in the induction of epithelial-to-mesenchymal transition (EMT) as a marker for onset of metastasis. In ectopic and orthotopic mouse models of colorectal cancer, bone marrow-derived CD11b(Itgam)(+)Jagged2 (Jag2)(+) cells infilt...
Introduction: Colorectal cancer is the third most common cancer in Iran. Some studies have shown that age and sex are associated with the course and prognosis of colorectal cancer. Due to the fact that recognizing the factors affecting colorectal cancer improves the screening system and selects better treatment modalities, and due to the lack of such studies in Iran, in this study, the relation...
Instability of microsatellites is a hallmark of the DNA replication error phenotype (RER+) due to the inactivation of mismatch repair genes. In humans, microsatellite instability has first been described in colorectal tumors developing in either hereditary nonpolyposis colorectal cancer or sporadic patients. Colorectal tumorigenesis in RER+ and RER- tumors is probably due to distinct mechanisms...
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of individuals at-risk. Colonoscopy and prophylactic colectomy decrease colorectal cancer incidence a...
Colorectal cancer (CRC) is the fourth most common malignancy worldwide, with 1.23 million patients diagnosed each year and a huge proportion of them characteristic early metastasis [1]. Usually, colorectal cancer mortality occurs in patients whose cancer cells metastasize to distant sites, such as the liver, lungs, brain, and bones. In detail, individual cells must reach the sites of metastasis...
Colorectal cancer is one of the most frequently diagnosed malignant tumors in men and women, which a highly heterogeneous group neoplasms consisting subclasses with different molecular clinical characteristics, and, as consequence, patients types require treatment protocols. Among predictive factors response metastatic colorectal cancer, studied are genes RAS family (KRAS, NRAS). Determination ...
Umbelliprenin is a sesquiterpene coumarin with vitro anti-carcinogenic activities. The aim of this study was to investigate the antitumor effects of umbelliprenin in animal models of colorectal cancer. The cytotoxic effects of umbelliprenin were explored on CT26 and L929by MTT assay. In this study, colorectal tumors developed in mice by intradermal injection of CT26 cell line. Tumor size, serum...
Umbelliprenin is a sesquiterpene coumarin with vitro anti-carcinogenic activities. The aim of this study was to investigate the antitumor effects of umbelliprenin in animal models of colorectal cancer. The cytotoxic effects of umbelliprenin were explored on CT26 and L929by MTT assay. In this study, colorectal tumors developed in mice by intradermal injection of CT26 cell line. Tumor size, serum...
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