abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

background: the aim of this study was to assess epidemiology of colorectal cancer (crc) in isfahan, iran. materials and methods: data were gathered from hospital documents of hospital admissions for colonoscopy, surgery, chemotherapy or radiotherapy due to colorectal cancer during 1996-2003. results: 1100 cases with colorectal cancer in seven years were detected and reviewed. our minimum incide...

introduction: colorectal cancer is the most common cancer of the alimentary system. in women, it is the second leading cause of mortality after breast cancer while in men, it is the third leading cause of death after lung and prostate carcinoma. prevalence is more in population older than 50 years and increases in older people. therefore, best treatment and prognosis is early diagnosis of disea...

aim : the aim of this study was to compare prognostic factors between colon and rectal cancers. background : prognosis of colorectal cancer (crc) may depend on the anatomical site. patients and methods : a total of 1219 patients with crc diagnosis according to the pathology report of rcgld cancer registry, from 1 january 2002 to 1 october 2007, were entered into the study. demographic and clini...

colorectal cancer is the second leading cause of cancer death worldwide. through risk assessment of malignancy in polyps, screening programs can achieve the best results. this study aimed to determine the association between the grade of dysplasia and the location of colorectal polyps. 240 colorectal adenomatous polyps which were referred to department of pathology at rasoul-e-akram hospital be...

background: the association between adenomatous polyps and malignancy has an important role in patient screening and follow up after polypectomy. due to less attraction towards the segmental resection, colonoscopic evaluation of malignancy has found its utmost importance role. polyp size and morphology have dictated the potential of malignancy in prior studies, however, in recent decade some au...

background: colorectal cancer is the third cause of cancer death in western countries. age, inadequate diet, obesity, inactivity and genetic changes are some of the risk factors of colorectal cancer. correlation of genetic diversity in homologous recombination repair system with cancer was evaluated in many recent studies. this study was done to investigate the correlation of t241m polymorphism...

aim : to investigate association between mthfr gene polymorphism with colorectal cancer. background : the enzyme 5,10-methylene-tetrahydrofolate reductase (mthfr) is linked to dna methylation, synthesis and repair. one of the most important polymorphisms that has been identified in the mthfr gene is c677t. the single nucleotide polymorphism c677t has been found to be associated with decreased e...