Lipomas are benign mesenchymal tumors of adipose tissue, though common at other sites, are rare in GIT. Most gastrointestinal lipomas are located in the colon, ileum and jejunum, are rarely responsible for clinical symptoms and are usually detected incidentally at colonoscopy. We present two such cases of large colonic lipomas. One is a 38-years old female presenting with complaint of loose sto...

Correspondence to: Daniela Radu:[email protected], M. Fernbach: [email protected], SUMMARY: Purpose: The present report was designed to evaluate how advanced colorectal neoplasm found at the moment of surgical treatment could represent a possible cause for high mortality rates. Main aim of this clinical study was to explore the current status of open surgery in the treatment of colorect...

Mature cystic teratomas account for 10-20% of all ovarian neoplasms and are the most common neoplasm in younger patients. Spontaneous rupture of the teratoma is rare and has been occasionally reported. Here we present an unusual case of left ovarian teratoma rupturing into sigmoid colon.

Background: Leiomyosarcoma (LMS) of sigmoid colon is an extremely rare neoplasm with poor prognosis, which is often misdiagnosed as colonic adenocarcinoma. The diagnosis of LMS depends on the pathology. The mitosis and the histological grade observation are important for diagnosis. Unlike gastrointestinal stromal tumor, c-KIT in LMS is negative, and immunohistochemistry examination is positive ...

Chronic inflammation is a well-recognized risk factor for development of human cancer in several tissues, including large bowel. Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer development. Several molecular events involved in chronic inflammatory process may contribute to...

Malignant rhabdoid tumors were originally described in children. Subsequently, the same histological pattern was described in adults. Malignant rhabdoid tumors are aggressive neoplasms that have been reported in multiple organs. To our best knowledge, only 16 previous cases of rhabdoid tumor in the colon have been described in the literature. We present the case of an 87-year-old lady who was d...

Spontaneously mutated multiple oncogenes and/or tumor suppressor genes in colon epithelial cell and its progeny, may cause proliferation out of control and create benign colon neoplasm (colon polyp). If additional mutations involve genes responsible for cell adhesion and movement, aberrant epithelial cells may become malignant (colon cancer) and invade surrounding and remote tissues, creating s...

The most frequently occurring lesions in the colon are the hyperplastic polyps. Hyperplastic polyps have long been considered as lesions with no malignant potential and colonoscopy for these patients is not recommended. However, recent works suggest that hyperplastic polyps may represent precursor lesions of some sporadic colorectal cancers. Until now, no biomarker allows to identify the subset...

Colon cancers arise from benign neoplasms and evolve into adenocarcinomas through a stepwise histological progression sequence, proceeding from either adenomas or hyperplastic polyps/serrated adenomas. Genetic alterations have been associated with specific steps in this polyp-adenocarcinoma sequence and are believed to drive the histological progression of colon cancer. Recently, epigenetic alt...