background colorectal cancer (crc) is one of the most common cancers worldwide which is not extensively researched in iran. objectives the present study aims to investigate the epidemiologic characteristics of crc in patients referred to selected hospitals of tehran university of medical sciences. patients and methods in this descriptive-analytic study 218 patients with colorectal cancer were i...

PURPOSE Several studies have shown an overexpression of cyclooxygenase-2 (COX-2) and elevated levels of prostacyclin (PGI(2)) and thromboxane (TXA(2)) in colon cancer. In this report, we determined the distribution of inducible form of nitric oxide synthase (iNOS), PGI(2), and TXA(2) in cancerous and adjoining areas of specimens from human colon and breast cancer obtained during surgery. Additi...

introduction: prostatic specific antigen (psa) is an important tumor marker of prostatic cancer and antigenic determinant of prostatic tissue. however, recently, results of several  researches have proposed existence of psa in non- prostatic tumors, extracts . in this study, our goal was to find that if patients with non-prostatic cancers synthesize psa. materials & methods : the sample was sel...

A 70-year-old woman with a history of lobular breast cancer presented to our Outpatient Clinic with diarrhoea for the past 3 years. Clinical examination and laboratory research were normal. Colonoscopy showed diffuse mild erythema and a decreased vascular pattern. Biopsies from the ascending colon, transverse colon, and descending colon showed metastases of lobular breast carcinoma. Although ga...

The Cancer is one of the world’s most devastating diseases. Doxorubicin (DOX) is an effective chemotherapeutic drug; however, its toxicity is a significant limitation in therapy. Due to the severe side effects of chemotherapy drugs, scientists have tried to load these drugs in nanocomposites. This paper describes a facile and low cost approach for preparation polymeric biodegradable nanohybrid ...

Background and aim: Colon cancer is the third most prevalent cancer in Iran. Prolonged colon inflammation is an important factor, in the development of colon cancer. Ginger has anti-inflammatory properties due to its content of [6]-gingerol and hence can play a role in the prevention of colon cancer. In this research the effects of ginger extract on reducing expression of the C...

there is still been no report of splenic involvement in the wake of colon cancer. in this case, air was seen in the spleen and liver following the penetration of colon cancer to the continuous spleen. colon cancers always do not present with clear and common symptoms. some times with a non-specific and uncommon symptoms and signs present that would be amazed physicians and researchers. it is ve...

background & aim: breast, cervical, and colorectal cancers are the leading causes of mortality among women, the incidence rate of which has an upward trend with advancing age. although cost-effective, easy, and available screening programs can help control these types of cancer in their early stages, it seems that cancer screening programs have not been implemented effectively. in this study, w...

BACKGROUND NSABP P-1 provides an opportunity to examine the association of behavioral factors with prospectively monitored cancer incidence and interactions with tamoxifen. METHODS From 1992 to 1997, 13,388 women with estimated 5-year breast cancer risk greater than 1.66% or a history of lobular carcinoma in situ (87% younger than age 65; 67% postmenopausal) were randomly assigned to tamoxife...