نتایج جستجو برای: codon 72

تعداد نتایج: 110241  

Journal: :World journal of gastroenterology 2006
Luis Orlando Pérez Martin Carlos Abba Fernando Noel Dulout Carlos Daniel Golijow

AIM To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development,and human papillomavirus (HPV) infection. METHODS One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed. p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reacti...

2008
Hung-Yu Lin Chun-Hsiung Huang Wen-Jen Wu Li-Ching Chang For-Wey Lung

TP53 is the most common mutated gene in human cancers. Approximately half of all human malignancies exhibit TP53 mutations. The TP53 codon 72 polymorphism is a single-nucleotide polymorphism (SNP) in exon 4, resulting in the expression of either arginine (CGC) or proline (CCC) residues. In this article, we review literatures published in MEDLINE, and attempt to describe how these two polymorphi...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Zun-Wu Zhang Paul Newcomb Andrew Hollowood Roger Feakins Moganaden Moorghen Alan Storey Michael J G Farthing Derek Alderson Jeff Holly

PURPOSE A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility and prognosis. To examine the role of the polymorphism in the gastric adenocarcinoma, we examined 397 patients with or without the cancer. EXPERIMENTAL DESIGN DNA samples were extracted from archived gastric tumor tissues and/or normal tissues of gastric adenocarcin...

2008
Mehdi Nikbahkt Dastjerdi Mansoor Salehi Mohammad Reza Mohajeri Fereshteh Morsali Hamid Mirmohammad Sadeghi Ebrahim Esfandiary

BACKGROUND: A common polymorphism at codon 72 of TP53 gene has been associated with increased risk for many human cancers. We studied this TP53 polymorphism in colorectal adenocarcinomas in small population selected from Isfahan city. METHODS: Samples: We undertook a case-control study on 180 controls and 180 paraffin block specimens of sporadic colorectal adenocarcinomas. PCR amplification of ...

2013
JING HOU YUAN JIANG WENRU TANG SHUTING JIA

p53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) on the risk of breast cancer; therefore, a meta-analysis was performed to estimate the association between the p53 codon 72 polymorphism and breast cancer. Screening of the PubMed database was conducted to ide...

2017
Venkat R. Katkoori Upender Manne Lakshmi S. Chaturvedi Marc D. Basson Pam Haan Daniel Coffey Harvey L. Bumpers

Background The codon 72 polymorphism in p53 has been implicated in colorectal cancer (CRC) risk, prognosis and CRC health disparities. We examined the functional consequence of this polymorphism in CRC. Experimental Design Plasmids (pCMV6) that express different phenotypes of p53 [p53 wild type (wt) at codon 72 (R72wt), R72wt with mutation at codon 273 cysteine (R72273Cys), p53 mutation at co...

2004
Kathrin Scheckenbach Oliver Lieven Karl Götte Ulrike Bockmühl Rainer Zotz Henning Bier Vera Balz

A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. Yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (HPV) infections, remains unresolved because of contradictory results. To address a potential correlation between the different ge...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999
Y C Wang C Y Chen S K Chen Y Y Chang P Lin

An association between the BstUI (Pro/Pro) genotype of the p53 codon 72 polymorphism and lung cancer has been reported previously (X. Jin et al., Carcinogenesis (Lond.), 16: 2205-2208, 1995). However, the genotype distribution of p53 codon 72 polymorphism as well as the association of this polymorphism with lung cancer risk and prognosis remain undefined in the Taiwanese population. Therefore, ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Shu-Pin Huang Wen-Jeng Wu Wun-Shaing Wayne Chang Ming-Tsang Wu Yun-Yun Chen Yun-Ju Chen Chia-Cheng Yu Tony T Wu Ying-Huei Lee Jong-Khing Huang Chun-Hsiung Huang

The tumor suppressor gene p53 and its downstream effector p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 at codon 72, and p21 at codon 31, have been found to be associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk. In this case-control study, we investigated the association of p53 c...

Journal: :Genetics and molecular research : GMR 2008
P S R Almeida W J Manoel A A S Reis E R Silva E Martins M V O Paiva A C Fraga V A Saddi

Soft tissue sarcomas (STS) are tumors of mesodermal origin, comprising about 1% of all adult neoplasms. Management of such tumors is an important medical challenge. TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer. We investigated p53 codon 72 ...

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