INTRODUCTION As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human tempo...

Introduction: As otology enters the field of gene therapy and human studies commence, the questionarises whether audiograms e the current gold standard for the evaluation of hearing function e canconsistently predict cellular damage within the human inner ear and thus should be used to defineinclusion criteria for trials. Current assumptions rely on the analysis of small groups of h...

Cochlear implantation may cause a detrimental effect on vestibular function and residual hearing. A significant number of patients with cochlear implant present vertigo. There are several mechanisms for dizziness following implantations. The causes be surgical trauma, disruption normal physiology, or ensuing endolymphatic hydrops. Vibratory trauma affecting the cochlea during cochleostomy plays...

Cochlear implant electrode arrays are designed with specific characteristics that allow for the preservation of intra-cochlear structures during the insertion process, as well as during explantation. Straight lateral wall (LW) electrode arrays and pre-curved modiolar hugging (MH) electrode arrays are the two types that are commercially available. Although there is a third type of electrode arra...

UNLABELLED Balance alterations in the postoperative of cochlear implant surgeries varies from 31 to 75%. AIM to analyze vestibular function in the pre and postoperative periods of cochlear implanted individuals. MATERIALS AND METHODS the vestibular function was assessed, through electronystagmography, in 38 patients, in the pre and postoperative of cochlear implant procedures. RESULTS The...

Bal ance alterations in the postoperative of cochlear implant surgeries varies from 31 to 75%. Aim: to analyze vestibular function in the pre and postoperative periods of cochlear implanted individuals. Materials and methods: the vestibular function was assessed, through electronystagmography, in 38 patients, in the pre and postoperative of cochlear implant procedures. The main complaint of unb...

Intense noise damages the cochlear organ of Corti, particularly the outer hair cells (OHCs) [1]; however, this epithelium is not innervated by nociceptors of somatosensory ganglia, which detect damage elsewhere in the body. The only sensory neurons innervating the organ of Corti originate from the spiral ganglion, roughly 95% of which innervate exclusively inner hair cells (IHCs) [2-4]. Upon so...

Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound stimuli, enriched in frequencies up to 20 kHz ("violet" noises) to examine th...