نتایج جستجو برای: coagulation inhibitors
تعداد نتایج: 234093 فیلتر نتایج به سال:
Disseminated intravascular coagulation (DIC) involves activation of clotting as well as fibrinolytic pathways. Thrombosis from thrombin release results in end-organ damage, whereas consumption of coagulation factors results in bleeding. Sepsis is the commonest cause of DIC. The consumption of antithrombin in sepsis abrogates its anti-inflammatory role and so its low level is a poor prognostic m...
Contrary to previous models based on plasma, coagulation processes are currently believed to be mostly cell surface-based, including three overlapping phases: initiation, when tissue factor-expressing cells and microparticles are exposed to plasma; amplification, whereby small amounts of thrombin induce platelet activation and aggregation, and promote activation of factors (F)V, FVIII and FXI o...
Critically ill patients (CIP) are patients who, because of dysfunction or failure of one or more organs/systems depend on advanced instruments for monitoring and therapy for their survival. Coagulation abnormalities are common in CIP. The most common (35–44%) is thrombocytopenia (platelet count less than 150,000/ ll), due to sepsis, disseminated intravascular coagulation (DIC), thrombotic micro...
During Gram-negative sepsis, lipopolysaccharide (LPS) activates toll-like receptor (TLR) 4 and induces complex responses of immune system and coagulation. However, the underlying LPS signalling mechanism on coagulation activation remains complex. To determine the role of the intracellular signalling factors p38 mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), and c-Jun N...
Angiogenesis is a multi-factorial process involving endothelial cells, pericytes, macrophages, angiogenic factors and inhibitors. It plays a fundamental role in many physiological and pathological processes such as wound healing and atherosclerosis. Haemostasis is the arrest of blood loss from damaged blood vessels involving platelet adhesion, activation and blood coagulation. Recent studies su...
Intravascular coagulation (IVC) was evaluated in 19 patients with type II and 11 with type IV hyperlipoproteinemia before and after clofibrate therapy by measurement of soluble fibrin complexes (SFC) in plasma; fibrinolysis was estimated by quantitation of fibrin (ogen) degradation products in serum. Untreated type II and type IV patients had increased SFC (P < 0.01). The former also had activa...
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway coagulation kallikrein–kinin system, respectively. Inhibition Factor XIIa (FXIIa), an initiator has been demonstrated to lead thrombo-protection anti-inflammatory effects in animal models serves as potentially safer target for development antithrombotics. ...
background: direct thrombin inhibitors and factor xa inhibitors are gaining popularity as alternatives to warfarin for patients requiring anticoagulation. toxicity due to these medications is difficult to manage because overdose experience is very limited and there is no clear guidance on when or whether to use antidote in this setting. case presentation: a 50-year-old man with normal renal fun...
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