BACKGROUND Adenotonsillectomy results in postoperative morbidity which otolaryngologists attempt to reduce by use of antibiotics. The regimes used as quite varied with some opting for a full oral course postoperatively while others prefer prophylactic doses. This randomised clinical trial done in Kenyatta National Hospital, Kenya had the aim of comparing the efficacy of Co-Amoxiclav given as a ...

and Klebsiella pneumoniae ATCC 700603 were used as control strains. The results were interpreted as per the CLSI (formerly NCCLS) criteria, except for ceftriaxone/sulbactam. Because there are no published breakpoints for the latter combination, the susceptibility criterion used for this combination was .8 mm increase in zone diameter of ceftriaxone/sulbactam in comparison with that of ceftriaxo...

BACKGROUND AND AIMS Jaundice associated with co-amoxiclav has been increasingly recognised. We aimed to characterise its clinical and histological features and to investigate linkage with human leucocyte antigen class II haplotypes. METHODS We identified cases in the west of Scotland in the period 1991-1997 and performed polymerase chain reaction amplification and oligonucleotide probing on w...

OBJECTIVES To explore the urine bactericidal activity of co-amoxiclav and norfloxacin against Escherichia coli in an in vitro pharmacodynamic model simulating the human urinary concentrations observed after administration of a single oral dose of 2000/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin. METHODS Six E. coli isolates exhibiting amoxicillin/clavulanic acid MICs of 4/2 (...

Introduction: Uropathogenic Escherichia coli (UPEC) is among the primary cause of urinary tract infections (UTIs). This study was conducted to determine the antibiotic resistance pattern of E. coli isolates from UTIs in Kermanshah. Methods: In this study, 180 midstream urine samples were collected from outpatients for five months. Based on differential biochemical tests such as oxidase, Indole,...

Melioidosis, infection with Burkholderia pseudomallei, is being recognised with increasing frequency and is probably more common than currently appreciated. Treatment recommendations are based on a series of clinical trials conducted in Thailand over the past 25 years. Treatment is usually divided into two phases: in the first, or acute phase, parenteral drugs are given for ≥10 days with the ai...