Background: Lymphoma of the central nervous system (CNS), both primary and secondary, represents a very rare part patients with non-Hodgkin lymphoma. Methods: Exams included neurological exam, laboratory blood tests, МRI, biopsy, electromyography. Results: Three different clinical cases lymphoma are presented. The first patient is 44-year-old male admitted to emergency room because neck stiffne...

A previously healthy 35 year old woman presented with bilateral uveitis associated with multiple, evolving, non-enhancing white matter lesions consistent with a progressive leukoencephalopathy such as multiple sclerosis. Thirty months after her initial presentation, she was diagnosed with primary CNS lymphoma and died 14 months later. The unusual clinical course preceding the diagnosis suggests...

Since 2007, West Nile virus (WNV) has been reported in South African horses, causing severe neurological signs. All cases were of lineage 2, except for one case that clustered with lineage 1 viruses. In the present study, gross and microscopic lesions of six South African lineage 2-infected horses and the one lineage 1 case are described. Diagnoses were confirmed by real-time reverse-transcript...

SARS-COV-2 is a neurotropic virus that can trigger large-scale outbreak of neurological complications in the future. has neuroinvasive and properties allow it to enter central nervous system (CNS) infect neurons, accumulate tissue promote development delayed neurodegenerative processes. Among SARS-CoV-2 date, we distinguish group demyelinating lesions CNS. The paper describes two cases severe C...

Objective NA. Background Design/Methods Results Primary CNS histiocytic sarcoma is a rare hematolymphoid malignancy with features of mature histiocytes and carries poor prognosis. We describe unique case in which 50-year-old woman presented recurrent acute brainstem syndrome, area postrema myelitis corresponding MRI lesions meeting diagnostic criteria for seronegative NMOSD. Despite initial imp...

Multiple sclerosis (MS) is an inflammatory disease of the CNS thought to be driven by CNS-specific T lymphocytes. Although CD8(+) T cells are frequently found in multiple sclerosis lesions, their distinct role remains controversial because direct signs of cytotoxicity have not been confirmed in vivo. In the present work, we determined that murine ovalbumin-transgenic (OT-1) CD8(+) T cells recog...

BACKGROUND Neospora caninum is an apicomplexan protozoan that is considered one of the main agents responsible for abortion in ruminants. The lesions found in the central nervous system (CNS) of aborted fetuses show multifocal necrosis, gliosis, and perivascular cuffs of mononuclear cells, but the inflammatory and glial cells have not been immunophenotypically characterized. The lesions in the ...

The injured central nervous system (CNS) can hardly regenerate. In vitro engineering of brain tissue hits technical bottlenecks. Also, the compaction and complexity anatomical structure defy accurate positioning for lesion sites in intracranial injuries. Therefore, repairing CNS remains a significant clinical challenge. Various recent vivo experiments have demonstrated excellent effect on nerve...

Fourteen patients with intraocular 'reticulum cell sarcoma' (non-Hodgkin's large cell lymphoma) ranging in age from 27 to 77 are presented. All patients had evidence of vitritis with 50% showing intraretinal and/or subretinal lesions and 21% having anterior uveitis. Five of the patients developed central nervous system lesions and subsequently died. Primary radiation therapy to the eyes and CNS...