Hyperphagia was induced in mice by p.o. administration of different types of CNS depressant drugs, like chlordiazepoxide 25 mg/kg diazepam 2.5 mg/kg, cyproheptadine 2 mg/kg and phenobarbitone 25 mg/kg. Such hyperphagia was abolished by pretreatment with naloxone 0.1 mg/kg sc. Naloxone per se at this dose produced no significant effect on the food intake. This is suggestive of the role of peptid...

Tulsi (Ocimum sanctum Linn.) herb has been known from as early as the Vedic period. Its extract has numerous pharmacological activities like hypoglycaemic, immunomodulatory, antistress, analgesic, antipyretic, anti-inflammatory, anti-ulcerogenic, antihypertensive, CNS depressant, radioprotective, antitumour and antibacterial. The active constituents of the herb include volatile oil chiefly euge...

In Australia, a study of 76 GHB users found they were stable, well-functioning, and highly educated. Some 29% typically drank more than five alcoholic drinks when using GHB and they had extensive experience with a range of other drugs which they used with GHB. But even though these users did not have a long or extensive experience with GHB, 99% reported at least one negative side effect. Of tho...

BACKGROUND Central nervous system-depressant (CNS-Ds) drugs can impair cognitive functions and driving. They are also the most common drugs taken in overdose in hospital-treated episodes of self-poisoning. In Australia most of these patients are discharged within 48 h, while they still have possible subclinical drug effects. We aimed to determine whether patients treated for self-poisoning with...

Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some an...

This study examined the effect of trans-dehydrocrotonin (DCTN), a 19-norclerodane diterpene isolated from Croton cajucara Benth (Euphorbiaceae), as analgesic and its effect on the central nervous system (CNS) of rodents using different animal models. The DCTN intraperitoneally exhibited mild analgesic activity on hot-plate test, but exhibited strong antinociceptive activity against acetic acid-...

In the present study methanolic and ethyl acetate extracts of Argemone mexicana whole plant (Papaveraceae) were tested orally in swiss albino mice at doses of 100 mg/kg, 200 mg/kg and 400 mg/kg b.w. for CNS related activities. Papaveraceae family is known to have CNS depressant activity, so A. mexicana was evaluated for CNS activities. Significant central and peripheral nociceptive activity was...