background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...

background: the purpose of this study was to evaluate antileishmanial effects of asa via no pathway in leishmania major infected balb/c mice. moreover, toxicity and pathological consequences of asa administration were investigated. methods: balb/c mice were infected with l. major and asa was inoculated orally after lesion appearance for its ability to modulate no and to modify leishmania infect...

INTRODUCTION Although the efficacy and safety of high dose hypoallergenic mite subcutaneous immunotherapy (SCIT) using a conventional administration schedule has already been demonstrated, there is no reported experience on the safety of these extracts with cluster schedules. We wanted to determine whether the use of a cluster schedule of a hypoallergenic allergen with a high concentration of h...

molecular farming, or bio-pharming, has recently received much of attention for production of valuable recombinant proteins, with a few already being marketed. the use of whole plants for synthesis of pharmaceutical proteins offers various advantages in economy, scalability and safety over conventional production systems. gm plants are suitable for the inexpensive production of large amounts of...

Interferon (IFN) therapy has been the standard of care for a variety cancers decades due to pleiotropic actions IFNs against malignancies. However, little is known about role copy number alteration (CNA) IFN gene cluster, located at 9p21.3, in cancer. This large individual patient data meta-analysis using 9937 patients obtained from cBioportal indicates that CNA cluster prevalent among 24 cance...

Methods We selected 3 adult patients with a confirmed diagnosis of severe persistent allergic asthma (ATS criteria for severe asthma) for at least five years. Mean average topical steroid (inhaled) daily dose was above 1000 mcg of fluticasone propionate or 1600 mcg of budesonide. All patients included in the current trial were clinically relevant sensitized to dust mites (Dermatophagoides spp.)...

It seems solid tumors are developing smart organs with specialized cells creating specified bio-territory, the so called "tumor microenvironment (TME)", in which there is reciprocal crosstalk among cancer cells, immune system cells and stromal cells. TME as an intricate milieu also consists of cancer stem cells (CSCs) that can resist against chemotherapies. In solid tumors, metabolism and vascu...

background: the use of dendritic cells (dcs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. it has been demonstrated that listeria mono-cytogenes activated dcs pulsed ex vivo with tumor antigens trigger a systemic th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. objective: the present study w...

To explore the development of global tumor immunotherapy in past 20 years, and analyze research status, hotspots trends to provide theoretical support for subsequent research. CiteSpace 5.6.R2 software were used 290 articles related from Web Science core data set 2000 2019. was draw visual maps tables coauthors, cooperating countries, institutions, literature journal co-citation, keyword co-occ...

this study evaluated the effects of mesobuthus eupeus (me) scorpion venom on inflammatory response following injection. additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after me venom inoculation. animals were divided randomly into four groups: the first group received ld50 of venom and the second and third gro...