Clotrimazole (CLT) has recently been shown to be a potent and specific inhibitor of the Ca(2+)-activated K+ channel and to thereby prevent K+ loss and cellular dehydration of sickled erythrocytes. This evidence suggests that oral CLT may be a useful new therapy for sickle cell disease. Here, we describe the development of an HPLC assay to measure CLT, a method we used to study the pharmacokinet...

Increased interleukin (IL)-8 plays an important role not only in activation and recruitment of neutrophils but also in inducing exaggerated angiogenesis at the inflamed site. In the present study, we investigated the fact that clotrimazole (CLT) inhibits intestinal inflammation, and the inhibitory action is mediated through suppression of IL-8 expression. In the trinitrobenzene sulfonic acid (T...

We read with interest the recent Critical Care review of post-extubation laryngeal edema and stridor resulting in respiratory failure [1]. We mostly agree with the authors’ opinion in that article except that the cuff leak test (CLT) was proposed as a standard extubation algorithm. We have two reasons to disagree. First, although the CLT has been widely used for the prediction of post-extubatio...

We have examined the effect of hydroxyurea (HU), clotrimazole (CLT), magnesium oxide (Mg), and combined CLT+Mg therapies on the erythrocyte characteristics and their response to chronic hypoxia in a transgenic sickle mouse (SAD) model. SAD mice were treated for 21 days with 1 of the following regimens (administered by gavage): control (n = 6), HU (200 mg/d; n = 6), CLT (80 mg/kg/d, n = 5), Mg (...

BACKGROUND We examine the clinical significance and biomarkers of tissue plasminogen activator (tPA)-catalyzed clot lysis time (CLT) in patients with intermediate-risk pulmonary embolism (PE). METHODS Platelet-poor, citrated plasma was obtained from patients with PE. Healthy age- and sex-matched patients served as disease-negative controls. Fibrinogen, α2-antiplasmin, plasminogen, thrombin ac...

It has been reported that papillary thyroid carcinoma (PTC) with chronic lymphocytic thyroiditis (CLT) is less associated with extrathyroidal extension (ETE), advanced tumor stage and lymph node (LN) metastasis. Other studies have suggested that concurrent CLT could antagonize PTC progression, even in BRAF-positive patients. Since the clinical significance of the BRAF mutation has been particul...

We compute the exact rates of convergence in total variation associated with the ‘fourth moment theorem’ by Nualart and Peccati (2005), stating that a sequence of random variables living in a fixed Wiener chaos verifies a central limit theorem (CLT) if and only if the sequence of the corresponding fourth cumulants converges to zero. We also provide an explicit illustration based on the Breuer-M...

How critical thinking is understood has a logical impact on pedagogy and curriculum design in education. If seen as complex mix of knowledge, skills dispositions that can be articulated made an object study themselves, then there scope for intentional explicit targeting such things. If, however, general skill more or less impermeable to pedagogical influence best realised through the developmen...

This paper focused on energy consumption and carbon emission for heating and cooling during a building’s operation stage, and examined the energy effects of using Cross Laminated Timber (CLT) as an alternative building material to reinforced concrete (RC) in China’s 31 key cities located in different climate zones. The authors designed two seven-story residential buildings, which were construct...