BACKGROUND Oxacillin and cloxacillin are the most frequently used penicillins for the treatment of severe methicillin-susceptible Staphylococcus aureus infections in intensive care units (ICUs), especially endocarditis. International recommendations do not suggest any adaptation of the dosage in case of renal impairment. We wanted to assess the risk factors for overdosing in ICU and the related...

Staphylococcus aureus invades eukaryotic cells. When methicillin-resistant S. aureus (MRSA) ATCC 33591 is phagocytized by human THP-1 macrophages, complete restoration of susceptibility to cloxacillin and meropenem is shown and the strain becomes indistinguishable from MSSA ATCC 25923 due to the acid pH prevailing in phagolysosomes (S. Lemaire et al., Antimicrob. Agents Chemother. 51:1627-1632,...

Sensitivity of Methicillin Resistant Staphylococcus aureus (MRSA) isolates purified from post operative wounds (n=100) from patients in surgical wards of Mayo, SIMS and Jinnah Hospital in Lahore-Pakistan was evaluated for antibiotics and plant extracts. The minimum inhibitory concentrations of ethanol extracts of medicinal plants (Opuntia delinii, Acacia nilotica and Aloe vera) and antibiotics ...

Lorber, J., Kalhan, S. C., and Mahgrefte, B. (1970). Archives of Disease in Childhood, 45, 178. Treatment ofventriculitis with gentamicin and cloxacillin in infants born with spina bifida. Of 783 newborn infants with spina bifida cystica and cranium bifidum treated in the 6 years to December 1966, 11% died of ventriculitis. 24% of all deaths were due to this cause. Experience with treatment of ...

Accepted 1 June 1995 A 37-year-old male drug addict was admitted to hospital because of a swollen right lower limb for two weeks. He had been using his groin for injection of heroin. He had been hospitalised three times six months earlier because of left lower limb deep vein thrombosis with or without Staphylococcus aureus septicaemia. He discharged himselfprematurely during the first admission...

INTRODUCTION Klebsiella pneumoniae is one of the main opportunistic pathogens which can cause different types of infections. Production of beta-lactamases like AmpC and ESBL mostly lead to beta-lactam resistance in these Gram-Negative bacteria. The aim of this study was the detection of AmpC-producing K. pneumoniae in clinical isolates. MATERIALS AND METHODS Three hundred and three isolates o...

Routine detection of AmpC beta lactamases in Escherichia coli is cumbersome. This study was performed to determine the usefulness of a modified disc diffusion test to detect AmpC beta lactamases in E.coli. 28 non-repetitive, cefoxitin resistant isolates of E.coli were collected from cases of urinary tract infections and screened phenotypically for ESBLs and AmpC beta lactamase using DDST (cefta...

A survey of antibiotic resistant Staphylococcus aureus strains from clinical specimens was carried out. A total of 100 different clinical specimens were investigated with a yield of 48 Staphylococcus aureus isolates. A high resistance of 95.8% to penicillin, 89.6% to ampicillin, 87.5% to tetracycline, and 75.0% to chloramphenicol by Staphylococcus aureus strains were recorded. A high susceptibi...