BACKGROUND Preemptive analgesia is the blocking of pain perception afferent pathways before noxious painful stimuli. Clonidine is an alpha agonist drug that is partially selective for α-2 adrenoreceptors. Clonidine is used as anti-anxiety medication and an, analgesic, and it prolongs the duration of the block in the brachial plexus block. OBJECTIVES To compare the effect of preemptive clonidi...

We tested the hypothesis that clonidine produces a dose-dependent increase in the sweating threshold but does not reduce the gain of sweating. Six healthy male volunteers were evaluated, each on three separate days in random order. In one, saline was administered; in another, a 2-micrograms/kg bolus of clonidine was followed by an infusion at 2 micrograms.kg-1.h-1, and on a third day, a 4-micro...

BACKGROUND Clonidine, a partial presynaptic and postsynaptic alpha-adrenoceptor agonist, has been shown to lower blood pressure in normal subjects but not in tetraplegics; however, the mechanisms of this action have not been elucidated. METHODS AND RESULTS The hemodynamic and hormonal basis of the hypotensive action of clonidine was investigated in tetraplegics with complete cervical spinal c...

Dexmedetomidine (DEX) is currently being used as a premedication for anxiolysis, an adjunctive drug both during and after surgery adjunct to attenuate emergence agitation, postoperative pain, shivering. It alpha-2 agonist which 8 times more potent than clonidine also has sympatholytic effects1. in central neraxial blocks enhance the quality prolong duration of block2,3. Its use peripheral nerve...

Clonidine is widely use as premedication in pediatric patients and has many beneficial effects in the perioperative period. The introduction of population pharmacokinetics in the 1980s has proven useful when performing pharmacokinetic studies in children to circumvent previous limitations with traditional pharmacokinetics. The aim of the current thesis was to further study the pharmacokinetics ...

BACKGROUND Impulsivity refers to a wide spectrum of actions characterized by quick and nonplanned reactions to external and internal stimuli, without taking into account the possible negative consequences for the individual or others, and decision-making is one of the biologically dissociated impulsive behaviors. Changes in impulsivity may be associated with norepinephrine. Various populations ...

BACKGROUND AND OBJECTIVES Induced arterial hypotension is an effective technique to decrease surgical bleeding. Clonidine is an a2-agonist with central action which was proven to be safe in anesthesia. This study aimed at evaluating the efficacy of intravenous clonidine as the primary drug for induced arterial hypotension. METHODS Participated in this prospective double-blind study 36 patient...

UNLABELLED Sevoflurane is frequently used as a rapidly acting drug for the induction of anesthesia. We investigated the awakening concentration (MAC-awake) of sevoflurane in ASA physical status I children (age range 2-10 yr). We also investigated the effects of two different doses of clonidine (2 and 4 microg/kg) on the MAC-awake of sevoflurane. Subjects were randomly divided into three groups ...

UNLABELLED The aim of this study was to compare hemodynamic responses to intubation and pin head-holder application in two groups of neurosurgical patients given oral clonidine (3 microg/kg) or oral temazepam (10-20 mg) 90 min before the induction of anesthesia. Fifty patients undergoing elective craniotomy were randomized to either group. Anesthesia was induced with i.v. propofol 1500 mg/h, fe...

Clonidine is an effective preanesthetic medication in children, providing a preoperative sedative effect. The analgesic properties of the drug have been well documented in adults. The current study was designed to investigate the effect of oral clonidine given preoperatively on postoperative pain in children undergoing minor surgery. In a prospective, randomized, controlled clinical trial, 90 c...