Department of A 21-year-old man presented with increased frequency of intermittent tonic spasms of 3 weeks’ Endocrinology and duration. There was also history of fever and extensive cutaneous lesions involving the body, scalp *Neurological Sciences, and nails of 6 weeks’ duration. From the age of 17 years, he experienced spontaneous paroxysmal Christian Medical tonic spasms involving extremitie...

Infantile spasm is an age-related refractory epilepsy. Topiramate is a new anticonvulsant with multiple mechanisms of action, and it may be effective for treating pediatric epilepsies. To evaluate the efficacy and tolerability of first-line topiramate treatment for infantile spasm, 20 patients received topiramate monotherapy during this study. They were treated with an initial dose of 1mg/kg/da...

To assess whether spontaneous coronary artery spasm in patients with variant angina results from local coronary hyperreactivity to a generalized constrictor stimulus or from a stimulus generated only at the site of the hyperreactive segment, the behavior of spastic and nonspastic coronary segments was studied in six patients with variant angina in whom focal coronary spasm developed spontaneous...

AIMS Contrast-guided axillary vein puncture is commonly used for pacemaker or defibrillator lead implantation. Venous spasm during contrast-guided axillary vein puncture has been reported rarely. We investigated the incidence of venous spasm during contrast-guided axillary vein puncture and the impact of venous spasm on axillary vein puncture. METHODS AND RESULTS Seventy-four consecutive pati...

Since the introduction of the water-soluble contrast agent metrizamide, reports of side effects in man following myelography have been limited to the frequent occurrence of relatively minor symptoms such as headache and vomiting , and the occasional episode of grand mal convulsions [17]. Such convulsions may relate to an excessive quantity of the contrast agent spilling over the convexity of th...

A copy of an ola leaf manuscript, the original of which was written around the late 1590s, was published recently. It describes the sequence of events leading to the death of the warrior King Rajasinghe of the Sithawake Kingdom (1521-1593). A study of the contents of this letter is presented. The dressing applied to a wound on the foot of the King is described in that letter. It is likely that ...

Ohtahara syndrome (OS) is a rare epileptic encephalopathy that is characterized by an abnormal electroencephalogram (EEG) and intractable seizures in the neonatal and early infantile period. The patient of this reported case was delivered normally at 39 weeks of gestation without any complication. One week after birth, seizures that were refractory to anticonvulsants started with repetitive clu...

OBJECTIVES To identify children with afebrile seizures in a national cohort, classify the seizures, and document progress in the first 10 years of life. DESIGN Population based birth cohort study. SETTING The child health and education study, which includes 16,004 neonatal survivors (98.5% of infants born in the United Kingdom during one week of April 1970). SUBJECTS 14,676 children for w...

In 1911, Oppenheim coined the term ‘dystonia’ to describe disordered motor control, characterised by an association of hypotonia and tonic muscle spasm. Focal hand dystonia is one form of this disorder, in which symptoms are often task-specific and occur during skilled movements such as writing (writer’s cramp) or playing a musical instrument (musician’s cramp). Much research has been conducted...

OBJECTIVES The aim of this study was to investigate the conformational change of arterial structure in the vasospastic lesion with optical coherence tomography. BACKGROUND Coronary artery spasm plays an important role in the pathogenesis of ischemic heart diseases. The conformational change of each arterial layer during vasospasm has not been studied in detail. METHODS We assessed 19 corona...