نتایج جستجو برای: clonazepam
تعداد نتایج: 849 فیلتر نتایج به سال:
The ability of the benzodiazepines, as a chemical class, to cause the induction and/or inhibition of cytochromes P450 has not been well characterized. In the present study, the induction of the cytochrome P450 2B subfamily (CYP2B) in vivo and the inhibition of CYP2B activity in vitro by selected benzodiazepines was examined in hepatic tissues derived from male F344/NCr rats. Initial studies of ...
BACKGROUND Anticonvulsant properties have been attributed to extracts of the herbal medicine Valeriana officinalis. Our aims were to examine the anticonvulsant properties of valerenic acid and valerian extracts and to determine whether valerian preparations interact with the activity of other anti-epileptic drugs (phenytoin or clonazepam). To achieve these goals, we validated the adult zebrafis...
The inhalation of 35% carbon dioxide has consistently been shown to provoke panic attacks in panic disorder patients. We aim to determine if an acute dose of clonazepam (2 mg) attenuates the panic attacks induced by an inhalation of 35% carbon dioxide in panic disorder. Twenty-two panic disorder patients who had been drug-free for 1 week participated in a carbon dioxide challenge test 1 h after...
The influence of nitric oxide (NO) on anticonvulsant activity of diazepam and clonazepam was examined in the pentetrazole- and electroshock-induced seizure models in mice. Protective efficacy of the threshold dose of diazepam against pentetrazole-induced clonic and tonic seizures, and death was significantly increased by NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) while 7-nitroindaz...
Objective: The aim of this cross-sectional study was to examine the prevalence of psychological dependence on antidepressants in outpatients with panic disorder and elucidate demographic and clinical characteristics associated with this condition. Methods: This study was conducted in four outpatient clinics in Tokyo, Japan from April, 2014 to March, 2015. Subjects were eligible if they were out...
Meige syndrome (MS) is a rare type of focal dystonia characterized by unintentional bilateral activity in facial and mandibular muscles combination with blepharospasm (spasm the orbicular muscle). Often unknown cause, MS can be primary (idiopathic) or secondary (to medications brain degenerative pathologies). Its treatment based most cases on botulinum toxin injections, not available our enviro...
Between January 2008 and August 2010, qualitative Google searches of 203 websites have been carried out in 8 European languages (English, German, Spanish, Italian, Dutch, Norwegian, Finnish, Swedish) using key words such as ‘legal highs’, ‘research chemicals’, ‘online pharmacy’, ‘Lyrica’, ‘pregabalin’, and ‘online pharmacies’. Out of these, 108 websites were monitored on a regular basis, i.e. d...
Benzodiazepines belongs to one of the most commonly used anxiolytic and anticonvulsant drugs in the world. Full description of toxic effects on different organs is lacking for nearly all the current benzodiazepines. The aim of the current work was to study the immunologic and vascular changes induced by sub-chronic administration of alprazolam and clonazepam in non-stressed and stressed adult m...
The influence of 1-(2-trifluoromethylphenyl)imidazole (TRIM) and 3-bromo-7-nitroindazole (3-Br-7-NI), potent and relatively selective inhibitors of neuronal nitric oxide (NO) synthase, on the antinociceptive and anticonvulsive effects of diazepam and clonazepam was investigated in mice. The effects were assessed in the writhing test and pentetrazole-induced seizures, respectively. The antinocic...
Seizures remain uncontrolled in 30% of patients with epilepsy, even with concurrent use of multiple drugs, and uncontrolled seizures result in increased morbidity and mortality. An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1.1. Studies ...
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