نتایج جستجو برای: cloisite 10a
تعداد نتایج: 1977 فیلتر نتایج به سال:
Commensal flora plays important roles in the regulation of the gene expression involved in many intestinal functions and the maintenance of immune homeostasis, as well as in the pathogenesis of inflammatory bowel diseases. The microRNAs (miRNAs), a class of small, noncoding RNAs, act as key regulators in many biological processes. The miRNAs are highly conserved among species and appear to play...
MicroRNAs (miRNAs) are small non-coding RNAs that can posttranscriptionally regulate gene expression by targeting messenger RNAs. During miRNA biogenesis, the star strand (miRNA*) is generally degraded to a low level in the cells. However, certain miRNA* express abundantly and can be recruited into the silencing complex to regulate gene expression. Most miRNAs function as suppressive regulators...
The steadily increasing incidence of kidney injury is a significant threat to human health. The current tools available for the early detection of kidney injury, however, have limited sensitivity or specificity. Thus, the development of novel biomarkers to detect early kidney injury is of high importance. Employing mouse renal ischemia-reperfusion and streptozotocin (STZ)-induced renal injury a...
Aims. MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD. Materials and Methods. Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n = 29), unstable angina pectoris (UAP) or non-ST elevation myocardial ...
The aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the protein synthesis. One to four hydroxyl functions of the small aminoglycoside neamine were capped with phenyl, naphthyl, pyridyl, or quinolyl rings. The 3',4'- (6), 3',6- (7a), and the 3',4',6- (10a) 2-naphthylmethylene derivatives appeared to be active against sensitive and resistant Staphylococcus aureus strains. 10...
BACKGROUND Although radiotherapy is one of the mainstream approaches for the treatment of head and neck squamous cell carcinoma (HNSCC), this cancer is always associated with resistance to radiation. In this study, the mechanism of action of isoalantolactone as well as its radiosensitizing effect was investigated in UMSCC-10A cells. METHODS The radiosensitization of UMSCC-10A cells treated wi...
Based on climate data and social statistics of Guangzhou observatory from 1952 to 2014,this paper used Linear trend analysis, Morlet wavelet transform analysis, Mann-Kendall mutation test etc., to analyze the trend of climate change in Guangzhou nearly 65 years. The results showed that climatic conditions in Guangzhou in recent 65 years showed a warming and drying trend and this trend had becom...
The sensitivity of human tumor cells to activated lymphocytes is considered to play an essential role in the antitumor activity of recombinant interleukin-2 (rIL-2)-based immunotherapy. We have investigated the effects of several genes involved in the regulation of cell growth and transformation on the sensitivity of human mammary epithelial MCF-10A cells to non-MHC-restricted, rIL-2-activated ...
توانایی تکثیر و تمایز سلولهای بنیادی خونساز تحت کنترل گروهی از ملکولهای ویژه متشکل از فاکتورهای نسخه برداری، سایتوکاین ها و همچنین گروه جدیدی ازrna های کوچک تنظیمی به نام micro rna(mir) ها میباشد. مطالعات متعددی بر روی شناسایی پروفایل بیان mir ها جهت تعیین نقش این ملکولهای کوچک در تمایز مگاکاریوسیتی سلولهای بنیادی خونساز انجام شده است. تحقیقات قبلی حکایت از کاهش بیان mir-10a و همچنین کاهش در سط...
MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR-10a-5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR-10a-5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW9...
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