background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...

introduction: the prevalence of hypertension in patients with type 2 diabetes (t2d) is approximately twice as much as healthy people. this study was designed to determine the effect of l-arginine supplementation on blood pressure in patients with t2d. methods: in a double-blind randomized clinical trial, 75 t2d were randomly divided into three groups (3 g/d and 6 g/d of l-arginine and placebo) ...

asparagus racemosus willd. has repeatedly been mentioned as a galactogogue in ayurvedic literature and has been confirmed through animal experiments as well. this randomized double-blind clinical trial evaluates its galactogogue effect in 60 lactating mothers by measurement of changes in their prolactin hormone level during the study. several secondary parameters namely mothers’ weight, babies’...

introduction:   palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy and tolerability of the combination of topical calcipot...

background menopause is a period of women’s lives with changes and symptoms that affect their work, sleep and quality of life. therefore, it is important to overcome these symptoms. objectives the aim of the present study was to compare the effects of calci soya balance and vitagnus on menopausal symptoms. patients and methods this double-blinded controlled trial study was performed in public h...

Background Independent oversight of clinical trials, recommended by Good Clinical Practice, is typically provided by an independent advisory Data Monitoring Committee (DMC) and an independent executive committee, to whom the DMC make recommendations. The detailed role and functionality of this executive committee, known as the Trial Steering Committee (TSC) have not been studied since proposed ...

objectives: to investigate the clinical efficacy of physiotherapy with and without superficial dry needling on patients with knee pain; patellofemoral pain syndrome. methods: a randomized clinical trial conducted in 2015, tehran, iran. of patients with patellofemoral pain syndrome, thirty-four subjects were randomly divided into two groups (17 in each group). group a was subjected to physiother...

introduction: vitiligo is a cutaneous disorder of pigmentation, for which, there are some proven modalities of treatment. in this study, we evaluated the efficacy of the addition of topical pimecrolimus to 308nm excimer laser in reducing treatment duration and improving the response rate of eyelid vitiligo, compared with 308nm excimer laser monotherapy. methods: fifty two symmetrically localize...