background and objective: bacterial meningitis is an important cause of mortality and long-term neural morbidity. immediate diagnosis and treatment are necessary in appropriate time. this study was designed in afzalipour hospital in kerman to evaluate meningitis causes, frequency and csf laboratory changes. patients and methods: in this retrograde descriptive study from september 2003 to septem...

INTRODUCTION Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human o...

Research of new diagnosis or prognosis biomarkers is a major challenge for the management of patients with complex pathologies like cancer. Clinical proteomics is one of the recent approaches to identify these biomarkers in biological fluids. Over the last five years, many problems related to the variability and the quality control of these analyses have been observed. This was notably related ...

Circulating tumor DNA (ctDNA) is released by cancer cells into body fluids. The collection of fluids that contains ctDNA, also known as lliquid biopsy, allows to access through a minimally invasive procedure. ctDNA has been proposed alternative source for genotyping purposes and longitudinal genetic monitoring. Also, radiation-free tool the early identification chemorefractory patients. We will...

As internists we like to think of ourselves as physicians with knowledge of disturbances of the milieu intérieur. Indeed, other specialities often call us for help when they are confronted with fluid and electrolyte disorders. The unrivalled number one of your electrolyte consults will undoubtedly be hyponatraemia. For example, hyponatraemia may arise in the postoperative period due to the comb...

Fluid management has been a vital part of routine clinical care for more than 180 years. The increasing number of available fluids has generated controversy about the optimal choice of resuscitation fluid. In this review, we provide a critical overview of the different fluids available, their composition, the relevant physiology as well as the published evidence on clinical outcomes to guide th...

Introduction The healthcare sector is nowadays one of the most dynamic sectors where the novelty is a strategic and operational imperative. The possibility of increasing the quantity and quality of clinical analysis, performed with instantaneous results and outside the clinical laboratories, contributes to a better quality in the healthcare services and to a better efficiency in the clinical an...

Biomarkers are present in all parts of the body including body fluids and tissues. Most of the clinical laboratory examinations are done on body fluids such as blood and urine. Biomarkers can be detected on imaging studies or examination of body tissues. Even exhaled breath contains biomarkers. A wide range of technologies is utilized for detection of biomarkers and a number of assays are alrea...

We assessed several methods of inorganic phosphate assay for their suitability in estimating phospholipids in digested extracts of amniotic fluids. The extraction and digestion procedures used for phospholipids from amniotic fluid were also examined critically. The effect of contamination by blood or obstetric cream has been examined. Accordingly, we suggest a method for measuring total phospho...

A pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis, and treatment through knowledge gained by the laboratory application of the biologic, chemical, and physical sciences. A pathologist uses information gathered from the microscopic examination of tissue specimens, cells, and body fluids, and from clinical laboratory tests on body fluids and secreti...