2’-Hydroxychalcones and murrayafoline A, a natural compounds isolated from Glycomis stenocarpa, have been reported to the promising anti-cancer activity. In this study, series of 2'-hydroxychalcones containing A (MuA) 6a-f were achieved by Claisen-Schmidt condensation key intermediate 5'-(1-methoxy-3-methyl-carbazolyl)methyl-2'-hydroxyacetophenone 4 with various aldehydes 5a-f purpose combining...

Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.

Hybrid catalysts: The high catalytic activity performance, stability and recyclability of “pyrrolidine type” fragments included in mesoporous silica for the preparation α,β-unsaturated compounds through base-catalyzed reactions such as Knoevenagel, Claisen-Schmidt Henry under microwave irradiation, contributing to development sustainable process, was reported.

A novel method for the synthesis of 2,6-dihydroxy substituted chalcones via Claisen-Schmidt is introduced using recyclable PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). The structures of the synthesized compounds were confirmed by IR, mass spectroscopy and elemental analysis.

Abstract Background The increase in resistance of pathogenic organisms to the available chemotherapeutic agents are critical challenges drug design and development, motivating researchers look for novel compounds that can combat multidrug-resistant organisms. Recently, chalcones have been proved be attractive moieties discovery. Results Eight triphenylamine with different substitution patterns ...

Pyrophosphate analogues are of great importance especially for the design of biologically active molecules. The phospha-Claisen condensation allows for the rapid synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues and building blocks that can be employed in numerous applications.

In this study, some novel mono- and di-O-β-D-glycopyranosyl chalcone analogs were designed, synthesized, characterized. The derivatives synthesized with good yields by base-catalyzed Claisen-Schmidt condensation in EtOH solution. Then these chalcones reacted TAGBr (2,3,4,6-tetra-O-acetyl-μ-D-glucopyranosylbromide) dry acetone under the anhydrous condition at 0-5 °C. Deacylated was carried out Z...

Transition metal‐free Claisen‐type condensation between two different amides was developed. N ‐phenyl‐ ‐tosylbenzamide derivatives reacted with enolizable such as ‐methyl pyrrolidinone and , ‐dimethyl acetamide in the presence of NaHMDS to give their corresponding β ‐ketoamides moderate‐to‐good yields.