نتایج جستجو برای: citicoline
تعداد نتایج: 431 فیلتر نتایج به سال:
Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5'-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately ...
To investigate the effect of citicoline adjuvant therapy on mild cognitive impairment (MCI) in Parkinson’s disease (PD) (PD-MCI) and its influence on plasma phospholipid (PL) levels in PD-MCI patients. The demographic data on 81 PD-MCI patients among 185 idiopathic PD patients who participated in the research from November 2012 to December 2014 were collected, and which were randomly divided in...
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on citicoline as a novel food ingredient in the context of Regulation (EC) No 258/97. The novel food ingredient (NFI), citicoline, is choline cytidine 5‟-pyrophosphate (C14H26N4O11P2) with a minimum purity of 98.0 %. The stability, specif...
A brief review is provided on the role of experimental modulation of the visual system during its plastic period. The importance of several substances has been demonstrated. Potential clinical applications of available studies on the treatment of amblyopia are summarized. The role of the dopaminergic system and particularly of dopamine in amblyopia are also discussed. The results of the use of ...
Sir, I read with great interest the article by Skripuletz et al. (2015), who showed beneficial effects of exogenously applied CDP-choline (citicoline) in murine myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) and in cuprizone-induced mouse model of demyelination. I would like to congratulate the authors for their report, which already has been recogni...
BACKGROUND Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger trial. METHODS We undertook a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke admitted at university hospitals ...
Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients' quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. Al...
Sir, I read with great interest the article by Skripuletz et al. (2015), who showed beneficial effects of exogenously applied CDP-choline (citicoline) in murine myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) and in cuprizone-induced mouse model of demyelination. I would like to congratulate the authors for their report, which already has been recogni...
Sir, I read with great interest the article by Skripuletz et al. (2015), who showed beneficial effects of exogenously applied CDP-choline (citicoline) in murine myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) and in cuprizone-induced mouse model of demyelination. I would like to congratulate the authors for their report, which already has been recogni...
This study examined the neurocognitive and electrophysiological effects of a citicoline-caffeine-based beverage in 60 healthy adult participants enrolled in a randomized, double-blind, placebo-controlled trial. Measures of electrical brain activity using electroencephalogram (EEG) and neuropsychological measures examining attention, concentration and reaction time were administered. Compared to...
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