نتایج جستجو برای: cisplatin toxicity
تعداد نتایج: 143067 فیلتر نتایج به سال:
Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the of agomelatine on cisplatin-induced toxicity in kidney liver. Animals were administered with a single dose (7 mg/kg, i.p.) treated (20 40 p.o) for seven days. Renal hepatic functions evaluated by measuring concentrations creatinine, BUN, AST ALT serum. Oxidativ...
Background: Ascorbic acid, known as vitamin C, has been used in combination with a number of cytotoxic agents in vitro and in vivo with contradictory results on its effectiveness. It is believed that vitamin C can sensitize different cancer cells to common therapy strategies such as chemotherapy and radiotherapy. During current research, the combination effect of vitamin C with cisplatin was ev...
To reduce the toxicity of cisplatin N-(2,3,4,5,6-pentahydroxylhex-1-yl)-N-dithiocarbamate-L-isoleucine disodium (GID) based therapeutic alliance is investigated. For the proliferation of HepG2, Hela, MES-SA, HL60 and H1299 cells, 27μM of GID based therapeutic alliance gave comparable inhibition to cisplatin alone. For implanted tumor proliferation in mice, 1.667μmol/kg of GID based therapeutic ...
Objective: Cancer is the most common cause of death after cardiovascular diseases. Cisplatin used in types cancer produces neurotoxicity. In this study, we aimed to investigate effects pomegranate peel extract (1) different doses, as potent antioxidants, on prevention neurotoxicity due cisplatin, which frequently treatment. Methods: our newborn rat cortex was used. 2 hours following application...
BACKGROUND Liposomal cisplatin is a new formulation developed to reduce the systemic toxicity of cisplatin while simultaneously improving the targeting of the drug to the primary tumor and to metastases by increasing circulation time in the body fluids and tissues. The primary objectives were to determine nephrotoxicity, gastrointestinal side-effects, peripheral neuropathy and hematological tox...
Whether nedaplatin and cisplatin are equally effective for advanced non-small cell lung cancer (NSCLC) remains uncertain. Therefore, we performed a meta-analysis of trials to compare nedaplatin-based chemotherapy with cisplatin-based chemotherapy. We conducted a literature search to identify trials that had investigated the substitution of nedaplatin for cisplatin in the treatment of advanced N...
OBJECTIVE This study aims to investigate the effect of intrapleural polymeric films containing cisplatin on the local recurrence of malignant pleural mesothelioma in a rat tumour model. METHODS An orthotopic rat recurrence model of malignant pleural mesothelioma was used. Five animals per group were evaluated. Polymeric films (4.5 cm diameter) for the local delivery of anticancer drug were co...
Cisplatin [cis-diamminedichloroplatinum(II)]/oxaliplatin [1,2-diamminocyclohexane(trans-1)oxolatoplatinum(II)] toxicity is enhanced by functional gap junctions between treated cells, implying that inhibition of gap junctions may decrease cytotoxic activity of these platinum-based agents. This study investigates the effect of gap junction modulation by cisplatin/oxaliplatin on cytotoxicity in a ...
OBJECTIVE Cisplatin can induce severe renal toxicity. However, the degree and pattern of hydration that is most efficient at preventing it have scarcely been formally evaluated. We here performed a prospective feasibility study of cisplatin-based chemotherapy with short-term low-volume hydration in advanced lung cancer. METHODS Chemo-naïve patients with advanced lung cancer and reserving rena...
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