The hydrodistilled oil of the aerial parts of Echiophora platyloba DC. was analyzed by GC and GC/MS. Ten components have been identified, of which the major constituents were found to be trans-b -ocimene (67.9%), 2-furanone (6.2%), myrcene (6.0%), linalool (3.1%), and cis-b -ocimene (2.3%).

amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Cadherin-mediated cell-cell adhesion is initiated by cis dimerization of cadherin ectodomains at the cell surface followed by an antiparallel trans interaction of dimers on opposing cells. To resolve open questions concerning the molecular details and specificity of cis and trans interactions, ectodomains of E- and P-cadherin were analyzed by chemical cross-linking and by electron microscopy. A...

Unsaturated spirocyclic substrates bearing two alkenyl chains underwent ruthenium-mediated ring-rearrangement metathesis through relaying cyclohexene and cycloheptene moieties to give angularly fused tricyclics. In some instances where two products were expected, high degrees of selectivity were observed. In one instance the structural parameter leading to selectivity was very subtle; in others...

Cylcohexanol is an essential bulk chemical that can be produced via cyclohexene hydration, a liquid-liquid two-phase reaction limited by the low rate and equilibrium conversion. Adding appropriate solvent most promising method to break through these limitations. However, in previous works was almost blindly selected without global consideration. In this work, rational multiscale proposed for ef...