نتایج جستجو برای: circumsporozoite protein
تعداد نتایج: 1234774 فیلتر نتایج به سال:
Abstract Background Plasmodium vivax contributes to over 70% malaria burden in Pakistan, but limited data exists on various aspects including genetic diversity of the parasite as compared other parts world. Since information about P. assists understand population dynamics parasite, current study was designed divergence Pakistan using circumsporozoite protein (pvcsp) and merozoite surface protei...
Malaria in Goa, India, has been endemic ever since an outbreak occurred in 1986. Anopheles stephensi Liston has always been suspected as a malaria vector in this area. Due to lack of knowledge on its resting behavior, sufficient adult females could not be collected and incriminated as vectors in the past. In this study mosquito collections were conducted in three endemic urban and suburban area...
Next Generation Sequencing to Detect Variation in the Plasmodium falciparum Circumsporozoite Protein
The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant produc...
The major surface protein of malaria sporozoites, the circumsporozoite protein, binds to heparan sulfate proteoglycans on the surface of hepatocytes. It has been proposed that this binding event is responsible for the rapid and specific localization of sporozoites to the liver after their injection into the skin by an infected anopheline mosquito. Previous in vitro studies performed under stati...
Abstract To induce long-lasting immunity, the host’s immune system must recognize and respond to an invading pathogen upon first encounter. Plasmodium sporozoites, infective stage of malaria parasite, are inoculated into skin by infected mosquitoes as they probe for blood. Only 20% sporozoites reach liver, while rest either draining lymph nodes (dLN) or remain in area at least 6 hours, shedding...
Structure of the Plasmodium falciparum Circumsporozoite Protein, a Leading Malaria Vaccine Candidate
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