The continual reassessment method (CRM) enables full and efficient use of all data and prior information available in a phase I study. However, despite a number of recent enhancements to the method, its acceptance in actual clinical practice has been hampered by several practical difficulties. In this paper, we consider several further refinements in the context of phase I oncology trials. In p...

PURPOSE To determine the spatial organization of the major cytoskeletal proteins and their relationship to the apical junctional complex (AJC) in the normal rabbit corneal endothelium. METHODS Normal endothelial cytoskeletal structure in three dimensions was studied in rabbit eyes by laser scanning confocal microscopy after en bloc immunocytochemical staining of whole corneal tissue with vari...

The in vivo circumferential strain has a small variation throughout the vascular system (aorta to arterioles). The axial strain has also been shown to be nearly the same as the circumferential strain under physiological loading. Since the endothelium is mechanically much softer than the media-adventitia in healthy arteries, the porcine intima was considered as a mechanically distinct layer from...

AIM We evaluated the validity of circumferential carotid artery strain as a marker for subclinical atherosclerosis and its benefit in addition to carotid intima-media thickness (IMT) to detect high-risk groups. METHODS The study was a cross-sectional study. From April 2007 to July 2008, 1057 patients who had undergone both echocardiography and carotid ultrasonography were consecutively enroll...

BACKGROUND Data on the comparative value of the circumferential pulmonary vein and the segmental pulmonary vein ablation for interventional treatment of atrial fibrillation are limited. We hypothesized that the circumferential pulmonary vein ablation approach was superior to the segmental pulmonary vein ablation approach. METHODS AND RESULTS One hundred patients with highly symptomatic atrial...

BACKGROUND AND PURPOSE Fixation of unstable trochanteric fractures is challenging. Application of a circumferential wire may facilitate bone contact and avoid postoperative fracture displacement. However, the use of circumferential wires remains controversial due to possible disturbance of the blood supply to the underlying bone. We evaluated the results of applied circumferential wires, concen...

Friction stir welding (FSW) is an excellent alternative process used in pipelines circumferential welds due to fusion welded joint low corrosion resistance. This study describes the resistance as a function of microstructural features resulting from API X70 FSW joint. The were examined by optical microscopy, scanning electron and x-ray diffraction. analysis was conducted employing potentiodynam...

the current study conducted a finite element (fe) and experimental investigation on tubular channel angular pressing as a noble severe plastic deformation technique for producing ultrafine grained and nanostructure tubular components. to examine the effects of the tcap process on the strain distribution and deformation behavior, fe simulations were employed. the fe results demonstrated that equ...

The states of penile erection have not been quantified to establish their relationship to intracorporal fluid pressure and to soft tissue constraint. Computer-based circumferential rigidity sensing during erectile cycles now permits circumferential size and rigidity characterization. Measurements during dynamic infusion cavernometry and cavernosography relate intracorporal pressure and axial ri...