نتایج جستجو برای: cinnamaldehyde dopaminergic neurons parkinsons disease

تعداد نتایج: 1644265  

Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were app...

Journal: :iranian journal of basic medical sciences 0
massoud amanlou department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran seyed davar siadat r and d and qc consultant & hepatitis and aids department, research and production complex, pasteur institute of iran, tehran, iran dariush norouzian r and d and qc consultant & hepatitis and aids department, research and production complex, pasteur institute of iran, tehran, iran mohammad reza aghasadeghi r and d and qc consultant & hepatitis and aids department, research and production complex, pasteur institute of iran, tehran, iran hadi fathi- moghaddam department of physiology and physiology research center, jundishapour university of medical sciences, ahvaz, iran mohhamad piryaei department of genetics, shahid beheshti university of medical sciences, tehran, iran

objective(s) the aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (gaba) ergic neurotransmission in normal and parkinsonian rats. materials and methods dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters c...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Matthew T C Brown Pablo Henny J Paul Bolam Peter J Magill

Dopaminergic neurons of the substantia nigra (SN) and ventral tegmental area (VTA) are collectively implicated in motor- and reward-related behaviors. However, dopaminergic SN and VTA neurons differ on several functional levels, and dopaminergic SN neurons themselves vary in their intrinsic electrical properties, neurochemical characteristics and connections. This heterogeneity is not only impo...

2008
Anke Brederlau

Directing stem cells and progenitors towards neuronal differentiation – implications for experimental therapies for Parkinson’s disease Anke Brederlau Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Sahlgrenska Academy at Gothenburg University, Sweden. The insight that stemand progenitor-cells contribute to replacement of nerve cells in the adult central nervous syst...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Yan Huang Zhan Liu Bei-Bei Cao Yi-Hua Qiu Yu-Ping Peng

BACKGROUND/AIMS Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in the nigrostriatal system. Herein, we show that Treg cells directly protect dopaminergic neurons against 1-methyl-4-phenylpyridinium (MPP+) neuro...

Journal: :Brain : a journal of neurology 2010
Chee Yeun Chung Pawel Licznerski Kambiz N Alavian Antonio Simeone Zhicheng Lin Eden Martin Jeffery Vance Ole Isacson

Two adjacent groups of midbrain dopaminergic neurons, A9 (substantia nigra pars compacta) and A10 (ventral tegmental area), have distinct projections and exhibit differential vulnerability in Parkinson's disease. Little is known about transcription factors that influence midbrain dopaminergic subgroup phenotypes or their potential role in disease. Here, we demonstrate elevated expression of the...

2004

Technology and target group: In Parkinsons disease, the brain cells that produce dopamine die. Approximately 15 000 patients in Sweden have Parkinsons disease. In its early stages, the disease can often be treated successfully by drugs. However, in most patients the disease progresses after a few years to a stage with complications where drugs no longer have a sufficient effect. In patients wit...

Journal: :Development 2006
Siew-Lan Ang

Although loss of midbrain dopaminergic neurons is associated with one of the most common human neurological disorders, Parkinson's disease, little is known about the specification of this neuronal subtype. Hence, the recent identification of major transcriptional determinants regulating the development of these neurons has brought much excitement and encouragement to this field. These new findi...

A Aflatoonian, M Bazrgar M Golestan jahromi, M Shahhoseini, P Afsharian R Aflatoonian

Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...

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