نتایج جستجو برای: cilostamide

تعداد نتایج: 89  

2014
Eric Féraille Eva Dizin Isabelle Roth Jean-Paul Derouette Ildiko Szanto Pierre-Yves Martin Sophie de Seigneux Udo Hasler

The final control of renal water reabsorption occurs in the collecting duct (CD) and relies on regulated expression of aquaporin-2 (AQP2) in principal CD cells. AQP2 transcription is primarily induced by type 2 vasopressin receptor (V2R)-cAMP-protein kinase A (PKA) signaling but also by other factors, including TonEBP and NF-κB. NAPDH oxidase 4 (NOX4) represents a major source of reactive oxyge...

Journal: :Cancer research 1989
G L Longenecker B J Beyers R J Bowen T King

The ability of tumor cells shed into the circulation to cause adhesion and aggregation of blood platelets may be involved in successful metastasis of primary tumors. Rhabdosarcoma is a rare, early metastasizing tumor previously uncharacterized for ability to alter platelet function. It was found that human rhabdosarcoma cells (American Type Culture Collection) dose dependently induce biphasic a...

Journal: :American journal of physiology. Heart and circulatory physiology 2003
Takayuki Matsumoto Tsuneo Kobayashi Katsuo Kamata

In isolated superior mesenteric artery rings from age-matched control rats and streptozotocin (STZ)-induced diabetic rats, we investigated the role of cAMP in endothelium-derived hyperpolarizing factor (EDHF)-type relaxation. The ACh-induced EDHF-type relaxation was significantly weaker in STZ-induced diabetic rats than in control rats, and in both groups of rats it was attenuated by 18alpha-gl...

Journal: :Zygote 2015
Sandra Milena Bernal Ulloa Julia Heinzmann Doris Herrmann Bernd Timmermann Ulrich Baulain Rudolf Großfeld Mike Diederich Andrea Lucas-Hahn Heiner Niemann

Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid spontaneous oocyte maturation and concomitantly improve oocyte developmental competence. The current work evaluated the effects of the addition of cAMP modulators forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cilostamide during in vitro maturation on the quality and yields of blastocysts. The following experimental gro...

2015
Beatriz Merino Ivan Quesada Jesús Hernández-Cascales Agustin Guerrero-Hernandez

This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this tissue. Isoproterenol increased both atrial frequency and contractility but glucagon only enhanced atrial rate. The transcript levels of glucago...

Azar Hosseini, Hamid Sadeghian Nasser Pour Ali Behzad Reza Shafiee-Nick,

Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...

Journal: :Journal of Molecular and Cellular Cardiology 2021

Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably regulation of L-type Ca2+ current (ICa,L). Cardiac hypertrophy (CH) is accompanied a reduction in PDE3 PDE4, however, whether this affects dynamic cytosolic ICa,L not known. Methods Results CH was induced rats thoracic ...

Ali Rahnama Isaac Karimi Mojdeh Salehnia Saeed Zavareh,

a:4:{s:10:"Background";s:513:"Therapeutic potential of in vitro maturation (IVM) in infertility is growing with great promise. Although significant progress is obtained in recent years, existing IVM protocols are far from favorable results. The first aim of this study was to investigate whether two step IVM manner change reactive oxygen species (ROS) and total antioxidant capacity (TAC) levels....

Journal: :Biology of reproduction 2011
Alberto M Luciano Federica Franciosi Silvia C Modina Valentina Lodde

Oocyte development is characterized by impressive changes in chromatin structure and function in the germinal vesicle (GV) that are crucial in conferring to the oocyte meiotic and developmental competence. During oogenesis, oocyte and follicular cells communicate by paracrine and junctional mechanisms. In cow, cumulus-enclosed oocytes (CEOs) isolated from early antral follicles have uncondensed...

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