BACKGROUND/AIMS Chronic urticaria (CU) is a common skin disorder characterized by wheals and pruritus lasting more than 6 weeks. Due to its long duration and changeable symptoms, the quality of life (QOL) of patients with CU can be impaired substantially. We evaluated the CU-QOL, a previously validated CU-specific QOL measure, and investigated factors influencing QOL in chronic spontaneous urti...

PURPOSE Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. METHODS The study group was composed of 54 children with CS...

BACKGROUND Parasites have been proposed to be an underlying cause of chronic spontaneous urticaria (CSU) in childhood, but a clear causal relationship between them has not been established. This study aimed to investigate the prevalence of parasitic infection-related CSU (PIRCSU) in children and to determine the factors associated with PIRCSU. METHOD Data from 211 children with CSU were analy...

In chronic spontaneous urticaria (CSU), different pathophysiological mechanisms, potentially responsible for the development of the disease, have been recently described. It is likely that the activation of skin mast cells with consequent release of histamine and other proinflammatory mediators is responsible for vasodilation in the lesional skin of CSU. However, the underlying causes of mast c...

BACKGROUND Chronic idiopathic or spontaneous urticaria (CIU/CSU) impairs patients' quality of life, and updated information on disease prevalence, treatment patterns, and disease burden is lacking. OBJECTIVES We aimed to estimate these figures in a large US real-world claims database via a validated algorithm. METHODS In this retrospective cross-sectional cohort study, we identified patient...

Background Chronic spontaneous urticaria (CSU) is more common in adults, especially middle-aged women. The condition resolves spontaneously within 6 months in 30 to 55% of patients but can persist for years in others. It has a devastating effect on the quality of life of those who experience it. Although the mechanisms are not fully elucidated, anti IgE recombinant humanized monoclonal (Omalizu...

Vitamin D plays an important role in the immune system; decreased serum vitamin D concentrations have been linked to dysregulated immune function. Low vitamin D status is probably associated with chronic spontaneous urticaria (CSU). We evaluated the prevalence of low vitamin D status, and the clinical response and quality of life following vitamin D supplementation, in a prospective case-contro...

INTRODUCTION Few studies have described chronic idiopathic/spontaneous urticaria (CIU/CSU) healthcare burden in adults, while this information remains largely unknown in children. We aimed to describe treatment patterns, healthcare resource utilization (HRU), and costs in CIU/CSU pediatric patients, as well as to compare HRU and costs in CIU/CSU and CIU/CSU-free pediatric patients. METHODS Me...

Abstract Purpose of review Urticaria is a frequent disorder that can present with erythema, edema, and pruritus involving the skin mucous membranes. Early diagnosis proper management urticaria according to type (i.e., acute vs chronic) utmost importance reduce burden disease prevent psychosocial comorbidities. In this review, we aim summarize chronic emphasis on differences. Recent findings Aut...

Autoimmune urticaria (AIU) is an important subset of chronic spontaneous (CSU) and can be relatively difficult to manage. Autologous serum skin test (ASST) has served as a useful bedside detect AIU its comparison with various blood biomarkers may unlock avenues in diagnosing autoimmune urticaria. Aim our study was assess role ASST CSU correlation relevant biomarkers. It hospital-based which 58 ...