The concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower disorders such as asthma, has been recognized for over a decade [...]

Background Early recognition of severe asthma may improve its management, modify its natural history by better approaching therapy and helps identifying patients resistant to current asthma therapy. Rhinitis and chronic rhinosinusitis are linked to asthma by clinical, epidemiological and similar inflammatory mechanisms which interrelates upper and lower airways. Evidence for high rate of chroni...

Introduction: Invasive fungal rhinosinusitis is a challenging condition that can be found mostly in immunocompromised patients. Failure to diagnose and treat this entity promptly usually results in rapid progression and death. The purpose of this study was to determine clinical presentation, complication and morbidity in patients with acute versus chronic invasive fungal rhinosinusitis. Setting...

it  is  well  known  that  desensitization  treatment  with  aspirin  can  significantly  improve symptoms and quality of life in patient with aspirin-exacerbated respiratory disease. however, its mechanism has not been clearly understood yet. in this case report, 41-year-old male patient was referred to our allergy and immunology department with complaints of chronic rhinosinusitis including p...

introduction: disorders of the nose and paranasal sinuses are among the most common chronic illnesses. although considerable progress has been made in the medical and surgical control of these diseases, a large number of questions relating to the diagnosis, evaluation, and treatment of these conditions remain unanswered. the aim of the present study was to evaluate differences in the frequency ...

Chronic rhinosinusitis (CRS) is one of the most common persistent disorders developed world, requiring input from various specialists including primary care physicians, otolaryngologists, respiratory and allergologists. B-cell lymphoproliferative (BLPDs) are a heterogenous group malignant conditions defined by an accumulation mature B lymphocytes in bone marrow, blood, lymphoid tissues. We pres...

Here, we report the draft genome sequences of Burkholderia pseudomallei and Staphylococcus aureus causing chronic rhinosinusitis. Whole-genome sequencing determined the B. pseudomallei as sequence type (ST) 1381 and the S. aureus as ST8. B. pseudomallei possessed the blaOXA-59 gene. This study illustrates the potential emergence of B. pseudomallei in cases of chronic rhinosinusitis.

OBJECTIVES/HYPOTHESIS Mucus hypersecretion is a hallmarks of chronic rhinosinusitis. The expression of MUC5AC, a major respiratory mucin gene, is increased in chronic rhinosinusitis. The mechanisms inducing mucus hypersecretion have not been fully evaluated in chronic rhinosinusitis. Human Ca2+ -activated Cl- channel 1 (hCLCA1) is implicated in the regulation of mucus production, airway fluid, ...

Chronic rhinosinusitis is a common disorder of chronic inflammation of the upper respiratory tract. It is associated with significant symptoms and impairment of the quality of life of sufferers. Despite recent advances in the medical and surgical management of chronic rhinosinusitis, there remains a population of patients who fail to obtain relief from their symptoms. Chronic inflammation of th...

BACKGROUND Recent otolaryngologic studies document significant fatigue and bodily pain (BP) in patients with chronic rhinosinusitis. Studies of general medical patients are lacking. METHODS A case-control study of 297 consecutive general medical outpatients. RESULTS Sixty-five patients noted unexplained chronic fatigue (UCF), 33 reported BP, and 26 had both. Compared with 232 patients witho...