It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpre...

for evaluation of drought tolerance of sugar beet genotypes by assessment of the drought tolerance indices under mild and severe stresses, furrow irrigated field experiments were carried out at zarghan research station in 2002 and 2004, and at motahari research station (located inkaraj) in 2002, 2003, and 2004. the experimental design was split plot, with a randomized complete block arrangement...

Title:Mechanism of Piper laetispicum extract (EAE-P) during Chronic Unpredictable Mild Stress is mediated by the interrelationship of inflammatory cytokines, apoptosis cytokines and neurotrophin in the hippocampus

Major depression is a complex psychiatric disorder characterized by affective, cognitive, and physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of this disabling condition, coupled with limitations in existing medications, make necessary the development of improved therapeutics. This requires animal models that allow investigation of key biological correl...

Objective: Chronic mild stress is the most valid model in inducing depression rodents. In this method, rats were subjected to CMS for 6 weeks of stress. Methods: rodents a series stressors six an unpredictable manner. Results: Biochemical and pathological changes observed. Lycopene treatment at 10 mg/kg 20 could revert these biochemical changes. Histopathological studies showed there neuronal l...

Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based metabolic profiling approach to investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi-criteria assessment for multivariate statistics could identify differential me...

This study demonstrates the changes in six different pathophysiological parameters such as body weight, body temperature, fecal pellet count, blood-brain barrier (BBB) permeability, plasma corticosterone level and emergence of hemorrhagic peptic ulcer spots due to exposure to high environmental heat in three different age groups of freely moving rats. Methods: Each age group of rats was sub di...

Acute and chronic stress have been reported to have differing effects on physical activity in rodents, but no study has examined a chronic stress protocol that incorporates stressors often experienced by rodents throughout a day. To examine this, the effects of the Unpredictable Chronic Mild Stress (UCMS) protocol on voluntary running wheel activity at multiple time points, and/or in response t...

This work evaluated the influence of chronic mild stress on latent inhibition (LI) in rats, using a conditioned emotional response (CER) procedure. Rats were assigned to four groups: a non pre-exposed control group (NPC), a non pre-exposed stressed group (NPS), a pre-exposed control group (PC), and a pre-exposed stressed group (PS). Stressed animals were submitted to a chronic mild stress (CMS)...