INTRODUCTION Atopic dermatitis is an important manifestation of the atopic diathesis.1,2 It not only frequently accompanies allergic respiratory disease but often precedes it as the initial clinical manifestation of allergic disease. The evaluation and management of patients with atopic dermatitis is therefore an integral part of an allergist’s practice and training. Since atopic dermatitis aff...

Cyclosporine is efficacious in short-term treatment of various eczematous disorders. In a follow-up study we have evaluated the long-term efficacy of cyclosporine in 75 patients, who in previous studies had been treated with cyclosporine for chronic actinic dermatitis (6 patients), atopic dermatitis (42 patients) and chronic hand eczema (27 patients), 4, 2 and 1 year after the initial treatment...

Data in literature seem to show that, in patients with contact allergic dermatitis, dietary nickel might be a cause of systemic dermatitis, but little information exists in literature about the role of nickel sensitization and dietary nickel in patients with allergic-like chronic dermatitis syndromes. The prevalence of nickel sensitization in patients with chronic allergic-like, non-IgE-mediate...

OBJECTIVE To assess the efficacy and safety of oral alitretinoin (9-cis-retinoic acid), 10 mg/d, 20 mg/d, and 40 mg/d, compared with placebo control, in the treatment of chronic hand dermatitis. DESIGN Multicenter, randomized, double-blind, placebo-control, prospective trial. SETTING A total of 43 outpatient clinics in 10 European countries. PATIENTS Of 348 patients screened, 319 with mod...

Atopic dermatitis is a chronic, itchy inflammatory skin disease of childhood characterized by papules. Its etiology is unknown and genetic and environmental factors play a role. This study was conducted to find out the changing trends in prevalence of atopic dermatitis. A questionnaire based study was conducted among 927 school going children of age group 4-18 years from November to December 20...

Atopic dermatitis is an inflammatory skin disease that most frequently occurred in children, but also common adults. The characterized as chronic, only 20% of children have severe atopic dermatitis, while the other 80% achieve a longterm remission by age 8 and earlier. article summarizes main details about including statistical epidemiological pathogenetic data, places special emphasis on issue...

Atopic dermatitis is a chronic, inflammatory skin condition that affects 10% to 20% of children and 1% to 3% of adults in the US. Symptoms often result in sleeplessness, psychological stress, poor self-esteem, anxiety, and poor school or work performance. The cost of atopic dermatitis is estimated to be US$0.9 to 3.8 billion every year. Topical steroids are first-line treatment for atopic derma...

The normal skin and other tissues of adult mast cell-deficient WBB6F1-W/Wv or WCB6F1-Sl/Sld mice contain less than 1.0% the number of mast cells present in the corresponding tissues of the congenic normal (+/+) mice. As a result, genetically mast cell-deficient WBB6F1-W/Wv or WCB6F1-Sl/Sld mice are widely used for studies of mast cell differentiation and function. We found that mast cells devel...

Atopic dermatitis is one of the most prevalent chronic inflammatory skin diseases, which can vastly influence patients quality life. Objective assessment severity required to select adequate therapy and evaluate its effectiveness. Heterogeneous clinical manifestations with greatly varying make it difficult assess atopic dermatitis. More than twenty methods are developed for this diseases severi...