Sir, Histological examination of the affected skin showed a granuloma consisting of lymphocytes, plasmacytes and, mostly, A 68-year-old man, on pharmacological substitution therapy for 10 years for the removal of a large pituitary adenoma with histiocytes. The routine blood work-up and the lymphocytic subpopulation assays resulted as normal. asymmetric expansion above the cella turcica, present...

A retrospective study was carried out to evaluate skin diseases associated with Chronic Granulomatous Inflammation at Pakistan Institute of Medical Sciences (PIMS) over a period of six months. There were a total of 249 skin biopsies in this period, among which 14.8 % cases were diagnosed as lesions associated with chronic granulomatous inflammation. Among these cutaneous leishmaniasis constitut...

Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving long term minocycline. The patient was receiving minocycline as suppression for chronic prosthetic joint infection. Risk factors associated with ...

Kaposi Irgang disease is a rare chronic from of cutaneous lupus. We describe case 28 years who was admitted for atrophic scars on both cheeks. The diagnosis systemic lupus with profound retained based immunological and biopsy results. She treated hydroxychloroquine referred to plastic surgery lopfilling.

conclusions mucomycosis should be in differncial diagnosis of any chronic infiltrative lesions even without visible necrosis and normal immune status of the patient. introduction cutaneous infection is an uncommon presentation of mucormycosis, usually seen after trauma, at the site of surgical drains or after occlusive dressings. the involved area is erythematous and painful, with varying degre...

BACKGROUND Extrahepatic manifestations are seen in association with chronic infection by hepatitis B or C virus including cutaneous disorders. The frequency of these findings seems to vary among different places and reports. There is a lack of information about this issue in Brazil. OBJECTIVES To estimate the prevalence of cutaneous findings affecting HBV or HCV carriers from a reference outp...

BACKGROUND Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. CASE PRESENTATION We present a case of a 57-yea...

co-infection of tuberculosis and leishmaniasis has been reported previously in patients with altered immune response due to primary or secondary immunodeficiency. these intracellular pathogens have a unique interaction in the host immune response and their development depends on impaired cell-mediated immunity. a case of chronic non-healing cutaneous ulcer with chronic fistulating soft-tissue m...

Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome, also called Neonatal Onset Multisystemic Inflammatory Disease (NOMID) is characterised by the triad of cutaneous rash, chronic meningitis and arthropathy. It is a chronic inflammatory illness that starts most often at birth and persists for the whole lifespan of the patient. Attempts at therapy have been disappointing. The...

Graft-versus-host disease is observed mainly in recipients of hematopoietic cell transplantation and is expressed by cutaneous or systemic signals and symptoms. Graft-versus-host disease is clinically classified as acute or chronic. Chronic Graft-versus-host disease occurs in up to 70% of hematopoietic cell transplanted patients and its clinical manifestations have important impact on morbidity...