Brucellosis is an infectious disease with high incidence in Iran. Neurobrucellosis is a focal complication of brucellosis affecting both central and peripheral nervous system presenting with a varieties of signs and symptoms. The most reported manifestations are meningitis and meningoencephalitis. In this report, we will describe a case of a young woman affected by neurobrucellosis presenting w...

RATIONALE Brucellosis is a multisystem infection found worldwide that has a broad range of characteristics, which range from acute fever and hepatomegaly to chronic infections that most commonly affect the central nervous system, cardiovascular system, or skeletal system. Gastrointestinal and splanchnic artery involvements in brucellosis are relatively uncommon. PATIENT CONCERNS We report a c...

Brucellosis is a zoonotic disease that often becomes chronic with a high rate of recurrence. To understand the cytokines induced during this infection we determined the levels of interleukin (IL)-1beta, IL-2, IL-4, IL-8, IL-12, tumor necrosis factor-of (TNF-alpha) and interferon-gamma (IFN-gamma) in serum of patients with brucellosis and compared with those without brucellosis and controls. Con...

Brucellosis is bacterial zoonoses. In endemic areas brucellosis can present with clinical features of nearly any neurological illness. Meningitic presentation is most common, with patient presenting with either acute or chronic meningitis. Pseudotumor--like presentation is also documented and accounts for only 4% of cases of neurobrucellosis. Here we are documenting a case of neurobrucellosis w...

et al. Spinal brucellosis. Br J Rheumatol 1987;26:28-30. 10. Al-Rawi ZS, Al-Khateeb N, Khalifa SJ. Brucella arthritis among Iraqi patients. Br J Rheumatol 1987;26:24-7. 11. Hodinka L, Gomor B, Meretey K, et al. HLA B27 associated with spondyloarthritis in chronic brucellosis. Lancet 1978;i:499. 12. Alarcon GS, Bocanegra TS, Gotuzzo E, etal. Reactive arthritis associated with brucellosis: HLA st...

Sir Brucellosis is the most frequent zoonotic infectious disease in the world, affecting more than 500 000 people every year (1, 2). Neurobrucellosis is a rare complication of brucellosis affecting the central and peripheral nervous system and causing serious clinical complications (3-6). Psychosis as a presentation of neurobrucellosis is a rare condition. There were only a few previous reports...

Ninety-two patients with brucellosis were studied for 18 months, and 15 to 29 sera from each patient were tested by the standard tube brucella agglutination test and by the 2-mercaptoethanol (2ME) brucella agglutination test. The standard tube test remained positive (greaterr than or equal to 160) for 1.5 years in 44 of the 92 patients (48%), despite adequate antibiotic treatment. The 2ME titer...

Resistance to intracellular bacterial pathogens such as Brucella spp. relies on cell-mediated immunity, which involves activation of the bactericidal mechanisms of antigen-presenting cells (macrophages and dendritic cells) and the subsequent expansion of antigen-specific CD4+ and CD8+ T-cell clones. Brucella antigens induce the production of T helper type 1 (Th1) cytokines, and an adequate Th1 ...

ALL the chronic granulomatous infections may occasionally give rise to ocular disease, and tuberculosis and syphilis are the best known in Great Britain. Brucellosis is an infection which should, at least in its chronic forms, be regarded as an important member of this group, and ought to be remembered as a possibility when the cause of certain eye diseases is being investigated. Standard text-...