نتایج جستجو برای: chronic allograft nephropathy

تعداد نتایج: 532196  

2017
Ai Katsuma Takafumi Yamakawa Yasuyuki Nakada Izumi Yamamoto Takashi Yokoo

Improvements in immunosuppression have reduced acute kidney allograft rejection and clinicians are now seeking ways to prolong allograft survival to 20 years and beyond. The primary cause of kidney allograft loss is still chronic rejection, followed by death with a functioning allograft and primary kidney disease recurrence. Thus, overcoming kidney allograft rejection remains the most important...

Journal: :Journal of the American Society of Nephrology : JASN 1999
S R Orth G Odoni K Amann P Strzelczyk M Raschack E Ritz

The effect of the orally highly bioavailable and specific endothelin A (ET(A)) receptor antagonist LU 135252 was assessed in a model of chronic renal allograft nephropathy. Kidneys of Fisher rats were orthotopically grafted to Lewis rats. Fisher autografts and kidneys after uninephrectomy served as controls. All animals received low-dose cyclosporin A (CsA; 1.5 mg/kg body wt) for 10 d after sur...

Journal: :Saudi Journal of Kidney Diseases and Transplantation 2013

Journal: :International Journal of Nephrology and Renovascular Disease 2014

Journal: :The American journal of pathology 2005
Judith Adams Eva Kiss Ana B V Arroyo Mahnaz Bonrouhi Qiang Sun Zhen Li Norbert Gretz Anna Schnitger Christos C Zouboulis Manfred Wiesel Jürgen Wagner Peter J Nelson Hermann-Josef Gröne

Chronic allograft nephropathy is characterized by chronic inflammation and fibrosis. Because retinoids exhibit anti-proliferative, anti-inflammatory, and anti-fibrotic functions, the effects of low and high doses of 13-cis-retinoic acid (13cRA) were studied in a chronic Fisher344-->Lewis transplantation model. In 13cRA animals, independent of dose (2 or 20 mg/kg body weight/day) and start (0 or...

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