Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived "null" variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variabilit...

Bilateral proliferative retinopathy is a rare complication of chronic myeloid leukemia (CML) as few case reports have been published to date. In this report, 32-year old diabetic female presented with history bilaterally decreased vision. Ophthalmologic examination showed bilateral (i.e., retinal detachment, vitreous hemorrhage, pre-retinal fibrosis and the presence peripheral capillary dropout...

The aim is to determine the epidemiological and cytogenetic profile (Philadelphia chromosome: Ph1) bcr-abl gene in patients with chronic myeloid leukemia (CML) assess therapeutic response of hydroxy-urea Imatinib treatment. From January 1, 2010 December 30, 2020, an observational study for diagnostic analytical purposes was carried out 54 cases CML at National Reference University Hospital (CHU...

A 75-year-old man with a 5-year history of myelodysplastic syndrome (MDS) subsequently developed worsening fatigue, dizziness, and dyspnea on exertion. There was no family history of hematologic diseases. On examination he was cachectic with no hepatosplenomegaly and petechiae, but purpuric lesions were present on his hands. The complete blood count showed pancytopenia (hemoglobin 10.2 g/dL, wh...

Fig. 1. G-banded karyogram from the patient’s bone marrow. Arrows indicate a t(1;8)(p36;q22). The t(8;21) translocation occurs in 5e12% of acute myeloid leukemia (AML) cases, often occurring in the younger population. This translocation fuses the RUNX1 gene (previously AML1) on chromosome band 21q22 to the RUNX1T1 (previously known as ETO) on 8q22, resulting in a RUNX1/RUNX1T1 hybrid transcript...