نتایج جستجو برای: chromosome 5q21
تعداد نتایج: 119353 فیلتر نتایج به سال:
Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide se...
conclusions this study revealed allele frequency of some strs on chromosome 12 and 16 for the first time in iran, and indicated differences between subjects with metabolic syndrome and subjects in the control group. results there was no significant deviation in allelic frequencies from hardy-weinberg equilibrium for all the studied markers except for d12s1632 and d12s329. the long alleles in d1...
Familial adenomatous polyposis (FAP) is a well-defined autosomal dominant predisposition to the development of polyposis in the colon and rectum at unusually early ages. The first symptoms of FAP are diarrhea and blood in the stool. Weight loss and weaknesses occur after the development of advanced tumour. The incidence of the FAP disorder is one per 10000 newborns. There are high levels of het...
رفتار میوزی برای اولین بار در زیر گونه crocus cancellatus subsp. damascenus (سیتوتیپ 2n=8a ) گزارش می شود. نتایج نشان می دهد که این زیر گونه (سیتوتیپ 2n=8a) دارای مجموعه کروموزومی 2n=8 و عدد گامتی n=4 می باشد. دو جفت کروموزوم به هستک متصل بود که تایید کننده حضور دو جفت کروموزوم قمردار در این زیر گونه می باشد. حضور یک عدد b کروموزوم در هر دو مرحله میوز و میتوز در این سیتوتیپ برای اولین بار گزارش...
We used a case-control study design to determine the association between bleomycin-induced chromatid breaks and the risk of lung cancer in general and by specific histopathological types. Lymphocytes from primary blood cultures of 78 controls and 75 cases with 4 histopathological types of lung cancer were treated with 0.03 unit/ml bleomycin for 5 h, and the frequency of induced chromatid breaka...
The I1307K mutation of the adenopolyposis coli gene (APC), located on chromosome 5q21–q22, is associated with an increased risk of cancer in Ashkenazi Jews. In the present study, we analyzed age and body mass of Ashkenazi Jewish prostate cancer patients, with and without the APC I1307K mutation. Participants in our study were found through urology and radiation oncology clinics, and all eligibl...
Gardner’s syndrome (GS) is a rare genetic disorder which is a variant of familial adenomatous polyposis (FAP). It is characterized by a coexistence of multiple intestinal polyps with bone and soft-tissue tumors, frequently impacted teeth or cutaneous and subcutaneous cystic lesions. The syndrome is caused by a mutation of the adenomatous polyposis coli gene (APC) located at chromosome 5q21. The...
Thymomas are thymic epithelial tumors. Because most of them are rich in nonneoplastic T-cells, recurrent genetic aberrations have been reported only in the rare, lymphocyte-poor WHO types A, B3, and C. We have now investigated virtually the whole spectrum of thymomas, including the commoner types AB and B2, microdissecting or culturing neoplastic cells from these lymphocyte-rich thymomas and ap...
Our laboratory has reported that two major noncollagenous dentin proteins, dentin sialoprotein and dentin phosphoprotein, are specific cleavage products of a larger precursor protein termed dentin sialophosphoprotein (MacDougall, M., Simmons, D., Luan, X., Nydegger, J., Feng, J. Q., and Gu, T. T. (1997) J. Biol. Chem. 272:835-842). To confirm our single gene hypothesis and initiate in vitro pro...
Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated wi...
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