Renal cell carcinoma (RCC) is one of the most common urological malignancies. In 2016, approximately 62,700 adults (39,650 males and 23,050 females) were diagnosed with RCC in the US and approximately 14,240 individuals died from renal neoplasm [1]. RCC mortality rate can vary between 26% up to 94% according to stage and aggressiveness of the disease [2]. RCC accounts for approximately 3% of so...

A sarcomatoid component can occur in all histologic subtypes of renal cell carcinoma (RCC) and indicates an aggressive tumor. It is reported in literature that the sarcomatoid component can resemble fibrosarcoma, malignant fibrous histiocytoma or rhabdomyosarcoma. We describe the case of a 59-years old patient diagnosed with a chromophobe renal cell carcinoma, presenting a very rare osteosarcom...

Emerging evidence has revealed that promyelocytic leukemia zinc finger may contribute in several ways to the development and progression of cancer, but no pan-cancer analysis its roles have been undertaken date. Here, we set out use bioinformatics techniques comprehensively investigate expression profiles prognostic significance finger, as well relationship clinic pathological parameters immune...

We report chromophobe renal cell carcinoma (CRCC) with sarcomatoid dedifferentiation in a sixty-five year old male. CRCC is a prognostically better, distinctive subtype of renal cell carcinoma (RCC), histologically characterized by cells containing translucent and reticulated cytoplasm with distinct cell borders. Sarcomatoid component accompanies 9% of CRCC which alters its prognostic implicati...

Renal cell carcinoma associated with fused ectopic kidneys has rarely been reported in the literature. Here we report the first case of robot-assisted heminephrectomy for chromophobe renal cell carcinoma in an L-shaped fused ectopic kidney. The present case report highlights the importance of three-dimensional vision and enhanced maneuverability with the EndoWrist technology of the robotic surg...

This review discusses the impact of molecular genetics on the diagnosis and prognosis of renal cell tumours as well as the genetic changes in renal cell tumours associated with von Hippel-Lindau disease and end-stage kidney disease. The use of molecular techniques enables the division of renal cell tumours into genetically and biologically well defined entities. The new classification system di...

It has been 35 years since Professor Thoenes and his colleagues discovered chromophobe renal cell carcinoma (RCC). Since then, our knowledge about this tumour entity changed novel entities have discovered. The aim of review is to discuss recent molecular findings open questions in diagnosing chromophobe-like/oncocytic neoplasms. broader differential diagnosis chromophobe-like oncocytoma-like ne...