The study of human protoporphyrinogen oxidase (hPPO) inhibition can contribute significantly to a better understanding some pathogeneses (e.g., porphyria, herbicide exposure) and the development anticancer agents. Therefore, we prepared new potential inhibitors with Schiff base structural motifs (2-hydroxybenzaldehyde-based bases 9–13 chromanone derivatives 17–19) as structurally relevant PPO h...

Microwave irradiation is used in the synthesis of four tricyclic chromanones 11-14. The chromanone 14 and 12 are selectively formed thermally and under microwave in the presence of polyphosphoric acid (PPA) from the same dicarboxylic acid 9, respectively. The crystal structures of the two diacids are also reported. The corresponding ortho and meta isomers of diacids crystallize in the space...

Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The key step was the preparation of chromane dione 5a by regioselective intramolecular c...