AIMS We investigated whether the treatment with anthocyanins prevents the scopolamine-induced memory deficits and whether ectonucleotidase activities and purine levels are altered in the cerebral cortex (CC) and hippocampus (HC) in this model of mnemonic deficit in rats. MAIN METHODS The animals were divided into 4 experimental groups: control (vehicle), anthocyanins (Antho), scopolamine (SCO...

We studied the efficacy of water-soluble extracts from four Ajuga spp on the post-embryonic development of two exopterygota (sucking insect) species. To allow comparison between different Ajuga species, results are expressed in terms of quantity of plant extracted per litre of test solution. Crude methanolic extracts of all Ajuga plants tested, with the exception of A genevensis, showed conside...

For warm-blooded species, the hazardous dose of a chemical (HD50) is an upcoming and important characteristic in the assessment of toxic chemicals. Generally, experimental information is available for a limited number of warm-blooded species only, which causes statistical uncertainty. Furthermore, when small datasets contain an unrepresentative sample of species, they can cause systematic uncer...

Adult male rats were given an oral dose of 10 mgkg aspartame “C-1abelled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (>98 % in plasma, >75 % in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of l-2 % of total radioactivity administered per g ...

People who supplement their diets with extra zinc usually have potentially harmful changes in lipoprotein metabolism. Because zinc can interfere with copper metabolism and copper deficiency has produced similar changes in lipid metabolism in animals and people, the hypothesis that lipid alterations from high zinc intakes are accompanied by changes in copper metabolism was tested. Progenies of s...

In 14 patients undergoing open-heart operations the haemodynamic effects of diazepam 0.4 mgkg(-1) followed by ketamine 2 mg kg(-1) were studied. In eight patients undergoing coronary bypass surgery, the mean arterial pressure decreased significantly after diazepam from 90.3 +/-7.4 (SEM) to 78.0 +/-5.0 mm Hg (P less than 0.05). However, no changes occurred in six patients undergoing valve replac...

Abstract Fly ash represents a promising alternative source of rare earth elements (REE). However, information on REE containing mineral phases and their association with other fly components, vital for recovery from ash, is currently lacking. Herein, the mass fraction, distribution, crystallography solid-state chemistry REE, U Th in Nigerian simulated samples were characterised using range labo...

The effects of three premedication regimens were compared in 45 healthy patients in whom anaesthesia was induced with diprivan 2 mgkg" I.V Premedication with diazepam 10 mg orally and droperidol 2.5-5 Omg and piritramide 7.5-15.0 mg i.m. resulted in less pain on injection and a more profound sleep from dipnvan than premedicanon with diazepam 10 mg orally or no premedication. No differences in s...

The effectiveness of 1,2-dimethyl-3-hydroxypyrid-4-one (Ll) in increasing iron excretion in iron-loaded patients improved the propsects for replacing desferrioxamine (DF) with an oral chelating drug.’,’ L1 belongs to a new group of iron chelators, the a-ketohydroxypyridines (KHP); which are cheap to p ~ e p a r e ~ . ~ and orally active. Recently, a detailed article by Porter et al.’ on in vivo...