We investigate the unimolecular dissociation of the vinoxy radical (CH2CHO) prepared with high internal energy imparted from the photodissociation of chloroacetaldehyde (CH2ClCHO) at 157 nm. Using a velocity map imaging apparatus, we measured the speed distribution of the recoiling chlorine atoms, Cl((2)P3/2) and Cl((2)P1/2), and derived from this the resulting distribution of kinetic energy, P...

In recent years the mathematical community has been enriched with various computer programs that facilitate and improve the learning of mathematics. Although many practical and didactical problems still exist, computer aided learning has become a valuable addition to education. However, these successes also lead to high expectations of teachers and learners. For a teacher it would be nice if he...

Metabolic activation of ifosfamide (IFO) leads to the active 4-hydroxy-metabolite and to a substantial liberation of chloroacetaldehyde (CAA). CAA has been presumed responsible for side effects of IFO. We recently have shown cytotoxic effects of CAA against human tumor cells in vitro. The aim of this study was to demonstrate antitumor effects of CAA in vivo, and to compare its potency to 4-OH-I...

Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...