Chlorhexidine gluconate is an effective bactericidal agent and broad-spectrum antimicrobial drug. It has been extensively researched and is the “gold standard” antimicrobial in oral hygiene. Chlorhexidine is useful in many clinical disciplines including periodontics, endodontics, oral surgery and operative dentistry. Introduction Chlorhexidine gluconate (chlorhexidine) is a broad-spectrum antim...

Editor—We read the article on the national audit conducted by the Royal College of Anaesthetists by Cook and colleagues 1 and congratulate the group on an outstanding piece of work which has enlightened the whole anaesthetic community and no doubt will lead to improved patient safety. We note that the NAP3 audit reinforces that sterile technique in regional anaesthesia is an important aspect of...

BACKGROUND Over the last decade, extremely-drug-resistant (XDR) strains of Klebsiella pneumoniae have emerged worldwide, mainly as a result of patient-to-patient spread. The predominant clone, sequence type 258 (ST258), is associated with high morbidity and mortality, and is a worldwide threat to public health. It was hypothesized that reduced susceptibility to chlorhexidine, the most widely us...

To the Editors:Your concerns regarding the recently published study, ‘‘A randomized trial that compared povidone iodine and chlorhexidine as antiseptics for vaginal hysterectomy,’’ are appreciated. First, by way of clarification, the literature search to which you refer did retrieve studies in which vaginal chlorhexidine had been used. In fact, we found 3 studies (including a total of more than...

INTRODUCTION Prosthetic mesh infection constitutes one of the major complications following hernia repair. Antimicrobial, non-antibiotic biomaterials have the potential to reduce bacterial adhesion to the mesh surface and adjacent tissues while avoiding the development of novel antibiotic resistance. This study assesses the efficacy of presoaking reticular polypropylene meshes in chlorhexidine ...

OBJECTIVES The increasing use of chlorhexidine for methicillin-resistant Staphylococcus aureus (MRSA) decolonization raises concerns about reduced susceptibility. We evaluated the carriage of chlorhexidine resistance genes and chlorhexidine susceptibility in MRSA before and after introduction of an institutional MRSA control programme incorporating chlorhexidine-based decolonization in 2004. ...

OBJECTIVES The in vitro pharmacodynamics of silver(I) and silver(II) complexes of a polydiguanide ligand, chlorhexidine, were assayed to examine the value of the bactericidal endpoint as an alternative means of evaluating their antibacterial activities against burn wound pathogens. METHODS Synthesis of silver(I) chlorhexidine [Ag(I)CHX] was accomplished by in situ precipitation of the complex...

Chlorhexidine is an antiseptic and disinfectant used in surgical and clinical practice since 1954 and is available in aqueous or alcoholic solutions 0.5%-4.0% and has a broad-spectrum activity. Despite their widespread use, allergic reactions with chlorhexidine are rarely reported. We describe a case of anaphylaxis with chlorhexidine during a septoplasty, turbinectomy, and maxillary sinusectomy...

conclusions bacterial resistance against chlorhexidine is increasing. sub-mic doses of chlorhexidine digluconate can stimulate the formation of biofilm strains. materials and methods forty clinical isolates of escherichia coli, salmonella serotypes, staphylococcus. aureus and streptococcus agalactiae (10 isolates for each) were examined for chlorhexidine digluconate effects on biofilm formation...