OBJECTIVE The objective of the research was to formulate and evaluate sumatriptan succinate-loaded chitosan nanoparticles for migraine therapy in order to improve its therapeutic effect and reduce dosing frequency. MATERIAL AND METHODS The Taguchi method design of experiments (L9 orthogonal array) was applied to obtain the optimized formulation. The sumatriptan succinate-loaded chitosan nanop...

Reverse microemulsion was used as a template to fabricate chitosan-alginate core-shell nanoparticles encapsulated with enhanced green fluorescent protein (EGFP)-encoded plasmids. The average size of DNA-entrapped nanoparticles measured by dynamic light scattering was increased proportionally, with the N/P ratios ranging from 5 to 20. These alginate-coated chitosan nanoparticles endocytosed by N...

The phenylboronic acid-conjugated chitosan nanoparticles were prepared by particle surface modification. The size, zeta potential and morphology of the nanoparticles were characterized by dynamic light scattering, zeta potential measurement and transmission electron microscopy. The cellular uptake, tumor penetration, biodistribution and antitumor activity of the nanoparticles were evaluated by ...

Purpose Escherichia coli O157:H7 is one of the most important pathogens which create hemorrhagic colitis and hemolytic uremic syndrome in human. It is one of the most prevalent causes of diarrhea leading to death of many people every year. The first diagnosed gene in the locus of enterocyte effacement pathogenicity island is eae gene. The product of this gene is a binding protein called intimin...

in this paper, fe3o4-chitosan nanoparticles were prepared by the immobilization of chitosan on the surface of fe3o4 nanoparticles. then, the 5-substituted hydantoins were synthesized from the condensation of aldehyde derivatives, ammonium carbonate and zinc cyanide as a well-known cyanating agent by the magnetic fe3o4-chitosan nanoparticles under neat conditions. fe3o4-chitosan nanocatalyst as ...

The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been ...

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin 13 poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These 14 excellent biological properties make chitosan a good candidate as platform for developing drug 15 delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced 16 pha...

The present study demonstrates non viral gene delivery using chitosan nanoparticles in Macrobrachium rosenbergii as model organism. Chitosan nanoparticles were synthesized by ionic gelation method. The mean particle size of chitosan nanoparticles was 27.6nm. The Polydispersity index was found to be 0.448 and zeta potential was +24.79mV. Green fluorescent protein encoding plasmid (PDB-402) was u...

We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately 100 nm, comprising C-erbB-2 siRNA packaged with chitosan, were prepa...

Chitosan is a natural polymer, which has been used in agriculture to stimulate crop growth. Furthermore, it has been used for the encapsulation of nanoparticles in order to obtain controlled release. In this work, the effect of chitosan-PVA and Cu nanoparticles (Cu NPs) absorbed on chitosan-PVA on growth, antioxidant capacity, mineral content, and saline stress in tomato plants was evaluated. T...