Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third ...

A 61-year-old female kidney transplant recipient presented with acute abdominal pain and chills. She was diagnosed with autosomal dominant polycystic kidney disease (ADPKD) at the age of 35 and had suffered from several renal cyst haemorrhages. She had been successfully transplanted with a kidney from a deceased donor 1 month earlier, after spending 5 months on haemodialysis; a right nephrectom...

Aesthetic chills are transient emotional responses to music or other experiences of beauty. Item 188 of the Revised NEO Personality Inventory (NEO-PI-R) asks respondents if they have experienced these chills, and in American samples it is one of the best definers of Openness to Experience, one of the five basic personality factors. As part of the NEO-PI-R, the item has been translated into over...

An 81yearold woman was brought to the emergency department with acute onset of shaking chills. She had no upper respiratory tract symptoms and chest, back, or abdominal pains before the arrival to the hospital. Her only regular medication was a nifedipine for hypertension. On examination, she was illappearing and had shaking chills. The blood pressure was 170/87 mmHg in the right upper extremit...