In the South West Pacific region, the striking geographical correlation between the frequency of alpha+-thalassemia and the endemicity of Plasmodium falciparum suggests that this hemoglobinopathy provides a selective advantage against malaria. In Vanuatu, paradoxically, alpha+-thalassemia increases the incidence of contracting mild malaria in the first 2 years of life, but severe disease was to...

Thalassemia is one of the most common genetic disorders in Egypt. With the total population of 70 million, there are approximately 600,000 affected individuals and more than 20 million thalassemia carriers. Thalassemia is therefore one of the major health problems in Egypt. B-Thalassemias are priority genetic diseases for prevention programs. Rapid genotype characterization is fundamental in th...

BACKGROUND The molecular defects resulting in a β-thalassemia phenotype, in the Egyptian population, show a clear heterogenic mutations pattern. PCR-based techniques, including direct DNA sequencing are effective on the molecular detection and characterization of these mutations. The molecular characterization of β-thalassemia is necessary for carrier screening, genetic counseling, and to offer...

Objectives: To assess the immunogenicity of Hepatitis B Vaccine in children with thalassemia.
 Study Design: Prospective longitudinal study.
 Place and Duration Study: Pak Emirates Military Hospital, Rawalpindi Pakistan from Aug 2018 to Jan 2019.
 Methodology: After ethical approval informed consent, 150 diagnosed patients thalassemia were selected Thalassemia centre at Hospital ...

UNLABELLED BACKGROUND Thalassemia is a common disorder worldwide with a predominant incidence in Mediterranean countries, North Africa, the Middle East, India, Central Asia, and Southeast Asia. Whilst substantial progress has been made towards the improvement of Health related quality of life (HRQoL) in western countries, scarce evidence-based data exists on HRQol of thalassemia children and...

Background Thalassemia is a common hereditary anemia in humans, and beta thalassemia represents a group of recessively inherited hemoglobin disorders first described by Cooley and Lee and characterized by the abnormal synthesis of β-globin chain. The homozygous state results in severe anemia, which needs regular blood transfusion. Although such treatments increase the patient's life span, a var...

background heart failure is a major cause of death in thalassemia. the study aimed to determine the diagnostic value of n terminal pro b type natriuretic peptide (nt-pro bnp), to early diagnose the cardiac involvement in beta- thalassemia major patients. materials and methods  80 thalassemia patients aged 7 to 18 years old (patients group), and 80 healthy age and gender matched controls were en...

BACKGROUND: Thalassemia is a genetic blood disorder and has not been cured. children need special attention from the family as one of efforts in treating with thalassemia depends on coping strategies owned by family. AIM: This research aimed to discover deeply explore caring for major aged 6–12 years. METHODS: study used quantitative qualitative approaches (mixed methods). For we total sampling...

OBJECTIVE Cardiac complications are the major cause of morbidity and mortality in beta-thalassemia major. The aim of the study was to evaluate right (RV) and left (LV) ventricular systolic and diastolic functions using myocardial performance index in young, asymptomatic children suffering from thalassemia major, for early detection of cardiac function impairment, preventing further cardiac dama...