introduction: acute lymphoblastic leukemia (all ) is the most worldwide common type of childhood cancer. methylenetetrahydrofolate reductase (mthfr) and 5-methyltetrahydrofolate-homocysteine methyltransferase (mtr) are crucial enzymes in folate pathways. folate availability is critical factor for dna integrity, required for the transfer of methyl group in the biosynthesis of thymidilate. proced...

Leukemia is the most common childhood cancer and accounts for 30-40% of all malignancies. A retrospective review  was performed of the hospital records of 9 children, 6 boys and 3 girls, aged  from 2.5 to 15 years with ALL initially referred to Nemazee hospital Nuclear medicine center for whole body bone scanning between 2000 and 2002. Bone marrow pathology established ALL (L1) in two and ALL (...

Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalize...

in this article, a mathematical model describing the growth orterminating myelogenous leukemia blood cancer's cells against naive t-celland eective t-cell population of body, presented by fractional dierentialequations. we use this model to analyze the stability of the dynamics, whichoccur in the local interaction of eector-immune cell and tumor cells. wewill also investigate the optima...

background: cancer is the third most common cause of death in iran, the leukemia cancer is one of the most important causes of cancer mortality. regarding cancer mortality, data would be important to monitor the program screening effects, earlier diagnosis, demographic data and other prognostic factors. the aim of this study was mortality rates evaluating, then leukemia cancer trends among the ...

Little is known about environmental causes of childhood cancer. This is probably due to the relative rarity of cancer in children. In the United States, cancer incidence in adults is over 20 times greater than cancer incidence in children. The situation is compounded by the fact that two groups of cancers, leukemias and brain and spinal tumors, account for half of all childhood cancers. The rar...

abstract background: the quantitative studies show that due to the widespread prevalence, high death rate, high treatment expenses, and long hospital stay, leukemia influences the families and their children to a great extent. in this regard, no qualitative study has been conducted in iran. so, this study was conducted in arak in 2011 with the aim of expressing the experiences of the parents wh...