Medulloblastoma is the most common form of childhood brain tumor, and management has evolved over the past two decades. Chemotherapy is now an integral part of the treatment of the majority, if not all, patients with this disease. Medulloblastoma is a chemosensitive tumor, and recurrent disease will often respond to a variety of different chemotherapeutic agents. The use of higher-dose chemothe...

MEK MEK162 GDC-0973 GSK1120212 MSC1936369B STAT3 OPB51602 AKT MK2206 Stage a Est. % General treatment recommendations 5-year overall survival b clinical stage path. stage IA 14% Surgical resection 50% 73% IB 10% Surgical resection, can consider adjuvant chemotherapy in selected cases (e.g. tumor size > 4cm) 43% 58% IIA 6% Surgical resection followed by adjuvant chemotherapy 36% 46% IIB 5% Surgi...

Evidence-based medicine integrates the best available data in decision making, with the goal of minimizing physicians' and patients' subjectivity. In 2006, the American Society of Clinical Oncology edited clinical practice guidelines for the use of larynx preservation strategies. The objective of this review was to evaluate the current levels of evidence for glottic squamous cell carcinoma. Cur...

PURPOSE Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas. The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients with radiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy. METHODS Three cases of leiomyosarcoma occurring 9-27 years after ...

background: quantification of radiation-induced apoptosis in peripheral blood lymphocytes (pbls) has been proposed as a possible screening test for cancer-prone individuals and also for the prediction of normal tissue responses after radiotherapy. materials and methods: the neutral version of the comet assay (single-cell gel electrophoresis) was used 24, 48, 72 hours after irradiation with 8 gy...