Pathway-specific gene delivery is requisite for understanding complex neuronal systems in which neurons that project to different target regions are locally intermingled. However, conventional genetic tools cannot achieve simultaneous, independent gene delivery into multiple target cells with high efficiency and low cross-reactivity. In this study, we systematically screened all receptor-envelo...

We have seen important strides in our understanding of mechanisms underlying stroke recovery, yet effective translational links between basic and applied sciences, as well as from big data to individualized therapies, are needed to truly develop a cure for stroke. We present such an approach using The Virtual Brain (TVB), a neuroinformatics platform that uses empirical neuroimaging data to crea...

in this study, the extract of sea cucumber species, holothuria leucospilota was extracted and its effect studied on the chemical quality rainbow trout fillets packed in vacuum. sea cucumber was extracted using methanol and various concentrations (0, 5/0, 1 and 2%) were prepared. salmon fillets after soaking in the extracts were vacuum packed, chemical tests every 4 days included total volatile ...

in this study, thyme extract (0, 2 and 4% w/v) on the chemical quality of common carp surimi was investigated during refrigerator storage. samples were withdrawn at four 3 days intervals over a storage period of 15 days (0, 3, 6, 9, 12 and 15 days), and analyzed to determine the extent of deterioration by chemical tests  such as thiobarbitoric acid (tba), total volatile bases nitrogen (tvb-n) a...

The study investigated the effect of 10% aqueous extracts ginger, garlic and onion on quality shelf life frozen chevon pork as reflected by changes in values 2-thiobartituric acid reactive substances (2-TBARS) total volatile basic nitrogen (TVB-N) over a 14 day storage under conditions.  pH, 2-TBARS TVB-N were measured from at -20°C after days. resulted low pH 5.63, 5.79 5.67 for mixed...

Hot-smoked rainbow trout (Oncorhynchus mykiss) fillets with vacuum packaging are an important export source and the manufacturers recommend a shelf life of 21 d at 4 °C. This time is very short in terms packaged foods. In this study, nisin lysozyme (0.5 1% w/v, respectively) were used order to prolong hot-smoked by adding them brine (8–10 ˚C, 10 h). Five treatment groups formed, including contr...

In this paper we consider Time-Varying Block (TVB) codes, which generalize a number of previous synchronization error-correcting codes. We also consider various practical issues related to MAP decoding of these codes. Specifically, we give an expression for the expected distribution of drift between transmitter and receiver due to synchronization errors. We determine an appropriate choice for s...

Avian leukosis virus (ALV) requires endocytosis and a low pH step for successful viral entry. Here we report that transient treatment with lysosomotropic agents was not sufficient to block ALV subgroup B (ALV-B) entry, while it completely inhibited uptake of the pH-dependent Semliki Forest virus. Extended incubations with lysosomotropic agents were required to block ALV-B entry, suggesting that...

Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...

Investigations were carried out on quality changes in salted and dried horse mackerel (Megalaspis cordyla). Sun drying (T1) and mechanical drying (T2) process for fish cured with salt were selected for estimating their efficiency and effect during six months storage period. Sun dried fish showed mean value of moisture, protein, ash and fat as 27.83 %, 54.13 %, 12.95 %, 5.99 %, respectively, whi...