نتایج جستجو برای: characteristic modes methods cms

تعداد نتایج: 2117118  

Journal: :Universal Access in the Information Society 2020

Journal: :Journal of medical genetics 2010
Karen Gaudon Isabelle Pénisson-Besnier Brigitte Chabrol Françoise Bouhour Laurence Demay Asma Ben Ammar Stéphanie Bauché Christophe Vial Guillaume Nicolas Bruno Eymard Daniel Hantaï Pascale Richard

Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders that give rise to a defect in neuromuscular transmission. We described here three patients with a characteristic phenotype of recessive CMS and presenting mutation in the gene encoding rapsyn (RAPSN). Familial analysis showed that one allelic mutation failed to be detected by direct sequencing. An allelic quant...

Journal: :The Journal of antimicrobial chemotherapy 2010
Sandrine Marchand Isabelle Lamarche Patrice Gobin William Couet

OBJECTIVES The aim of this study was to evaluate the effect of colistin methanesulphonate (CMS) dose on CMS and colistin pharmacokinetics in rats. METHODS Three rats per group received an intravenous bolus of CMS at a dose of 5, 15, 30, 60 or 120 mg/kg. Arterial blood samples were drawn at 0, 5, 15, 30, 60, 90, 120, 150 and 180 min. CMS and colistin plasma concentrations were determined by li...

2012
Anil Aggarwal Veena Adlakha Terry Ross

The Internet is creating exciting opportunities for universities and their stakeholders. Universities are experimenting with different modes of education. E-learning is one such mode, where students can learn from any place at any time, as long as they have an Internet connection. A course management system (CMS) facilitates e-learning, making it critical to select a system that can meet the ne...

Journal: :Brain : a journal of neurology 2007
Juliane S Müller Agnes Herczegfalvi Juan J Vilchez Jaume Colomer Linda L Bachinski Violeta Mihaylova Manuela Santos Ulrike Schara Marcus Deschauer Michael Shevell Chantal Poulin Ana Dias Ana Soudo Marja Hietala Tuula Aärimaa Ralf Krahe Veronika Karcagi Angela Huebner David Beeson Angela Abicht Hanns Lochmüller

Dok ('downstream-of-kinase') family of cytoplasmic proteins play a role in signalling downstream of receptor and non-receptor phosphotyrosine kinases. Recently, a skeletal muscle receptor tyrosine kinase (MuSK)-interacting cytoplasmic protein termed Dok-7 has been identified. Subsequently, we and others identified mutations in DOK7 as a cause of congenital myasthenic syndromes (CMS), providing ...

2014
Yu Zhang Wei Yang Dongsheng Han Young-Il Kim

Environment monitoring is important for the safety of underground coal mine production, and it is also an important application of Wireless Sensor Networks (WSNs). We put forward an integrated environment monitoring system for underground coal mine, which uses the existing Cable Monitoring System (CMS) as the main body and the WSN with multi-parameter monitoring as the supplementary technique. ...

Journal: :The Journal of antimicrobial chemotherapy 2004
Jian Li Robert W Milne Roger L Nation John D Turnidge Timothy C Smeaton Kingsley Coulthard

OBJECTIVES To determine the disposition of colistin methanesulphonate (CMS) and colistin following intravenous (iv) administration of CMS in rats. METHODS Five rats received a single iv bolus of 15 mg/kg CMS. Plasma concentrations of CMS and of colistin formed by the hydrolysis of CMS were determined by HPLC. The pharmacokinetic parameters of CMS and colistin were calculated using non-compart...

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