Sickle cell disease is an autosomal recessive hematological disorder resulting from a missense point mutation in the beta chain of haemoglobin molecule. This article reports case homozygous sickle adult patient with long-standing history non-healing ulcer

The complete molecule of the title compound, C 26 H 34 O 6 , is generated by a crystallographic centre symmetry and central octyl chain adopts an extended conformation. In structure, weak C—H...π interactions link molecules.

The superantigen staphylococcal enterotoxin A (SEA) binds to major histocompatibility complex (MHC) class II molecules at two sites on either side of the peptide groove. Two separate but cooperative interactions to the human class II molecule HLA-DR1 were detected. The first high affinity interaction to the DR1 beta chain is mediated by a zinc atom coordinated by H187, H225, and D227 in SEA and...

A semiflexible Gaussian chain model is used to determine the statistics and correlations of single-molecule fluorescence resonant energy transfer ~FRET! experiments on biological polymers. The model incorporates a persistence length in a Rouse chain and describes single-chain dynamics with normal modes. The hydrodynamic interaction is included in the dynamics of the semiflexible Gaussian chain ...

Controlling electron transport through a single-molecule device is key to the realization of nanoscale electronic components. A design requirement for single molecule electrical devices is that the molecule must be both structurally and electrically connected to the metallic electrodes. Typically, the mechanical and electrical contacts are achieved by the same chemical moiety. In this study, we...

INTODUCTION Amphiphilic polymers, such as poly(alkyl methacrylate)s and poly(alkyl acrylamide)s, are known to form stable monolayers on a water surface by the Langmuir–Blodgett (LB) method.1,2 The polymer monolayer has an ultimate thinness of the size of the monomer unit, and it has few defects in the film plane. Therefore, the monolayer of an amphiphilic polymer has attracted much interest as ...

We studied the effect of branched-chain polyamines on the folding transition of genome-sized DNA molecules in aqueous solution by the use of single-molecule observation with fluorescence microcopy. Detailed morphological features of polyamine/DNA complexes were characterized by atomic force microscopy (AFM). The AFM observations indicated that branched-chain polyamines tend to induce a characte...

A procedure for the isolation of bovine Factor V has been developed. The Factor V is isolated from bovine plasma by a series of steps including barium citrate adsorption, polyethylene glycol precipitation, QAE-cellulose adsorption, hydrophobic chromatography on octyl Sepharose, ammonium sulfate fractionation, preparative electrophoresis on acrylamide gels, and finally, phenyl Sepharose chromato...

this study concerns about quantum chemical modeling behavior of 02 on cr (100)surface by using density functional theory (dft) by lanl2dz and 6 — 31g* basissets, we presented the results of our first principles electronic structure calculationson the 02 molecules and their interface with cr (100) surface. the chromium metalhas the body-centered cubic structure, and chromium cluster has five cr ...