Protein tyrosine phosphatase 1B (PTP1B), a major negative regulator of the insulin and leptin signaling pathway, is a potential target for therapeutic intervention against diabetes and obesity. The recent discovery of an allosteric site in PTP1B has created an alternate strategy in the development of PTP1B targeted therapy. The current study investigates the molecular interactions between the a...

Charge hydration asymmetry (CHA)-a characteristic dependence of hydration free energy on the sign of the solute charge-quantifies the asymmetric response of water to electric field at microscopic level. Accurate estimates of CHA are critical for understanding hydration effects ubiquitous in chemistry and biology. However, measuring hydration energies of charged species is fraught with significa...

Sub-Saharan Africa (SSA) has the highest prevalence rate of HIV/AIDS in the world, with negative effects on productivity, profitability, economic growth, and development. The social responsibility role of public companies in contributing towards reducing the negative effects of HIV/AIDS is priceless. This paper investigates the impact of corporate governance (CG) on social and environmental acc...

We reviewed the results of 51 patients with benign bone tumours treated by curettage and implantation of calcium hydroxyapatite ceramic (CHA). The mean follow-up was 11.4 years (10 to 15.5). Post-operative fractures occurred in two patients and three had local recurrences; three had slightly limited movement of the adjacent joint and one had mild osteoarthritis. There were no allergic or neopla...

An in vitro marrow culture assay designed to measure erythropoietic capability was used to ascertain the presence of an inhibitor in the sera of patients with congenital hypoplastic anemia (CHA). Marrow cells from nine anemic CHA patients responded to the stimulatory effect of exogenous erythropoietin (EPO) by an increase in heme synthesis in the presence of normal serum. The effect on heme syn...

OBJECTIVE To evaluate the impact of the presence of a congenital heart anomaly (CHA) and its potential contribution to morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). METHODS In this retrospective cohort study, prenatal and postnatal data of all newborns diagnosed with CDH between January 2004 and December 2012 in a single center were reviewed. Cases were classi...

BACKGROUND Patients with myocardial infarction (MI) are at risk of the development of atrial fibrillation (AF) and ischemic stroke. We sought to evaluate the prognostic performance of the CHADS₂ and CHA₂DS₂-VASc scores in predicting new AF and/or ischemic stroke in post-ST segment elevation MI (STEMI) patients. Six hundred and seven consecutive post-STEMI patients with no previously documented ...

The adaptable choosability number of a multigraph G, denoted cha(G), is the smallest integer k such that every edge labeling of G and assignment of lists of size k to the vertices of G permits a list coloring of G in which no edge e = uv has both u and v colored with the label of e. We show that cha grows with ch, i.e. there is a function f tending to infinity such that cha(G) ≥ f(ch(G)).

325 SINGLE PORT ACCESS VERSUS CONVENTIONAL LAPAROSCOPIC OVARIAN CYSTECTOMY: COMPARISON OF SURGICAL OUTCOMES Yoon Jung Lee, MD, Myung Joo Kim, MD, Seok Ju Seong, MD, In Hyun Kim, MD, Mi La Kim, MD, Taejong Song, MD, Bo Sung Yoon, MD, Yong Wook Jung, MD, Won-Duk Joo, MD, Hye Sun Jun, MD Department of Obstetrics and Gynecology, CHA Gangnam Medical Center; CHA Daegu Women’s Medical Center, CHA Univ...

Chaetoglobosin Fex (Cha Fex), a cytochalasan-based alkaloid, was isolated from marine-derived endophytic fungus Chaetomium globosum QEN-14. The knowledge of its biological function is still limited. We investigated the effects and mechanism of Cha Fex on inflammatory mediators via Toll-like receptor 4 (TLR4) signaling in macrophages. Lipopolysaccharide (LPS), TLR4 ligand, was therefore designed...